Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity

By Naotada Ishihara, Y. Eura, K. Mihara. Journal of Cell Science, 2004

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View Paper: https://www.semanticscholar.org/paper/914a76de2c800bdaa5424df5ba9bbd2b36475b21

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Citations in the corpus

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease (2012, background): “The mitofusins are transmembrane proteins that span the outer mitochondrial membrane; they form homo- or heterodimers upon fusion initiation and utilize their GTPase activity to fuse the membranes together [39,40].”
Mitochondrial dynamics in mammalian health and disease. (2009, background): “This difference is in agreement with the higher tethering and GTPase activity observed in Mfn1-harboring mitochondria and purified Mfn1, respectively, compared with Mfn2 (144).”
Mitochondrial fission in apoptosis (2005, background): “MFN1 mediates tethering of mitochondria more efficiently than MFN2 does, and requires GTP hydrolysis for this functio”
Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation (2011, background): “A prominent role for Mfn1 in effecting mitochondrial fusion during starvation is consistent with evidence implicating Mfn1 as the primary driver of mitochondrial fusion activity, whereasMfn2 has a more diverse set of functions, including responsibility for endoplasmic reticulum– mitochondria tetheri”
Regulation of mitochondrial morphology through proteolytic cleavage of OPA1 (2006, methodology): “Co-immunoprecipitation experiments using digitonin-solubilized mitochondria were performed as described (Ishihara et al, 2004).”
Mitochondrial dynamics and apoptosis. (2008, positive): “The C-terminal coiled-coil region of Mfn1 and Mfn2 mediates tethering between mitochondria through homo- or heterotypic complexes formed between adjacent mitochondria (Chen et al. 2003; Ishihara et al. 2004; Koshiba et al. 2004; Meeusen et al. 2004).”
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. (2006, positive): “MFN2 is presumed to have mostly a regulatory role (Ishihara et al., 2004), while MFN1 tethers two juxtaposed organelles (Koshiba et al.”
Mitochondrial fusion and fission in mammals. (2006, background): “OPA1 function shows a dependence on Mfn1 but not on Mfn2 (Cipolat et al. 2004), and Mfn1 shows more activity in a mitochondrial tethering assay (Ishihara et al. 2004).”
Mitochondrial fragmentation in neurodegeneration (2008, background): “In addition, MFN1 and MFN2 have been found to form homo-oligomeric and hetero-oligomeric complexes in trans”
The role of mitochondria in apoptosis. (2008, background): “Because that Drp1, Mfn2, and Bax co-localize at fission sites during apoptosis (94), fission proteins may interact with Bax during apoptosis.”