Inhibition of Macroautophagy Triggers Apoptosis

By P. Boya, R. González-Polo, N. Casares, J. Perfettini, Philippe Dessen, N. Larochette, D. Métivier, D. Meley, S. Souquere, T. Yoshimori and 3 more. Molecular and Cellular Biology, 2005

1,716 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Parasitology

View Paper: https://www.semanticscholar.org/paper/d4222c7f8bd0b9d4dff1c9946389484e8839de83

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Citations in the corpus

Lysosomes and autophagy in cell death control (2005, background): “For example, the knock-down of ATG5 , ATG10 or ATG12 (which are all involved in a ubiquitin-like conjugation system required for autophagosome formation) prevents the generation of autophagic vacuoles and sensitizes HeLa cells to starvation-induced cell deat”
Molecular definitions of autophagy and related processes (2017, neutral): “…inhibitors of macroautophagy as well as genetic interventions targeting various components of the macroautophagy machinery generally accelerate (rather than retard) the demise of cells experiencing perturbations of homeostasis (Boya et al , 2005; Yousefi et al , 2006; Mrschtik et al , 2015).”
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. (2007, background): “During starvation autophagy is a temporary survival mechanism, as self-digestion provides an alternative energy source (Boya et al. 2005; Degenhardt et al. 2006).”
Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells (2008, methodology): “The siRNA specific for human beclin-1 was purchased from Dharmacon (Lafayette, CO, USA) and the sequences used were same as those by Degenhardt et al.29 The siRNA specific for atg-5 was purchased from Sigma Proligo (The Woodlands, TX, USA) and the sequences used were same as those by Boya et al.38 a”
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress (2007, result): “This inverse correlation between the extent of autophagy and apoptosis is in agreement with a previous report that the inactivation of autophagy triggers apoptosi”
Autophagy-Independent Functions of the Autophagy Machinery (2019, background): “In mammalian cells, bona fide autophagic responses most often mediate robust cytoprotective effects (Boya et al., 2005 ; ”
Regulation of autophagy by cytoplasmic p53 (2008, background): “Inhibition of this autophagic response reduces cell survival in most instance”
The roles of intracellular protein-degradation pathways in neurodegeneration (2006, background): “, enhances susceptibility to certain types of apoptosi”
The role of autophagy in cancer development and response to therapy (2005, background): “Conversely, the use of autophagy inhibitors such as 3-MA, or inhibition of autophagy by small interfering RNAs (siRNAs) targetted against autophagy-associated genes, induced apoptosis in HeLa cell”
Autophagy in cell death: an innocent convict? (2005, background): “RNAi against beclin 1, atg5, atg10, and atg12 enhances starvation-induced, but not staurosporineinduced, apoptotic cell death (36).”
Autophagy: from phenomenology to molecular understanding in less than a decade (2007, background): “In most situations, autophagy probably functions initially as a cytoprotective mechanism, but if cellular damage is too extensive, or if apoptosis is compromised, excessive autophagy may be used to kill the cel”
Oxidative Stress and Autophagy (2006, neutral): “Although the mechanisms coordinating these processes during oxidative stress are still unknown, for other stress conditions such as nutritional stress, activation of macroautophagy prior to the insult has been shown to “prep” the cells making them more resistant to the cellular damage (8).”
Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy (2007, background): “Recently, several studies have reported that autophagy may serve as a protective response.(21,24,25) Thus, we hypothesized that upregulation of autophagy serves as a protective response against Bnip3-mediated injury likely by sequestering damaged mitochondria.”