Oxidative Stress and Autophagy
By R. Kiffin, Urmi Bandyopadhyay, A. Cuervo. Antioxidants and Redox Signaling, 2006
704 citations recorded by the source corpus.
Organisms respond to oxidative injury by orchestrating a stress response to prevent further damage. An increase in the intracellular levels of antioxidant agents, and at the same time the removal of already damaged components, are both part of the oxidative stress response. Lysosomes have been classically considered one of the main targets of the reactive oxygen species. In fact, the destabilization of the lysosomal membrane during oxidizing conditions promotes the leakage of the enzymes contained in these organelles and contributes to cellular damage. However, recent evidence supports a protective role of the lysosomal system, which can eliminate altered intracellular components through autophagy, at least in the first stages of oxidative injury. Consequently, activation of the main intracellular proteolytic systems, the ubiquitin/proteasome, and also the lysosomal/autophagic system occurs during the oxidative stress response. The opposing roles for the lysosomal system under oxidizing conditions are discussed in this review. Antioxid. Redox Signal. 8: 152–162.
Subfields: Epidemiology, Parasitology, Physiology
View Paper: https://www.semanticscholar.org/paper/1feb85e59222c0370062ffa3bd5768f45c6661b6
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Citations in the corpus
- Reactive oxygen species in plants: their generation, signal transduction, and scavenging mechanisms (2011, background): “TOCs are lipophilic antioxidants synthesized by all plants and also essential components of biological membranes (Kiffin et al., 2006).”
- The roles of intracellular protein-degradation pathways in neurodegeneration (2006, result): “These data are also compatible with the suggestion that autophagy reduces susceptibility to oxidative stres”
- Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 (2007, background): “The data available till now, linking ROS with autophagy, describe the death-related pathway, known as type II PCD, which is induced by high levels of ROS (i.e. oxidative stress; Yu et al, 2004; Kiffin et al, 2006).”
- Signal transduction during cold, salt, and drought stresses in plants (2011, background): “H2O2 induces accumulation of stress hormones, such as salicylic acid (SA) and ethylene [146].”
- Mechanisms of Cell Death in Oxidative Stress (2007, neutral): “Thus, recent evidence suggests that PKC isoforms may regulate various aspects of the apoptotic program, however the mechanisms and isoform specificity of these interactions are not completely”
- Reactive oxygen species signaling in plants under abiotic stress (2013, background): “α-tocopherol along with other antioxidants scavenges lipid peroxy radical.(8,16) It acts as lipophilic antioxidant and interacts with polyunsaturated acyl groups of lipids and reduces the deleterious effects of ROS.”
- Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment (2009, positive): “In addition to the cellular antioxidant systems discussed earlier, autophagy is also used in cellular defense against oxidative stress (52, 78).”
- Reactive oxygen species (ROS) and response of antioxidants as ROS-scavengers during environmental stress in plants (2014, background): “…redox state of the cell. α-Tocopherol The α-tocopherol belongs to a family of lipophilic antioxidants which are efficient scavengers of ROS and lipid radicals, making them indispensable protectors and essential components of biological membranes (Holländer-Czytko et al., 2005; Kiffin et al., 2006).”