Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells

By Yongqiang Chen, E. McMillan-Ward, J. Kong, S. Israels, S. Gibson. Cell Death and Differentiation, 2008

684 citations recorded by the source corpus.

Subfields: Epidemiology, Geriatrics and Gerontology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f20633f8b3c682600e8bc240e82ec2b20875c354

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In Molecular Biology

1. P. Chiarugi
2. E. Giannoni
3. M. Duennwald
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Citations in the corpus

• Anoikis molecular pathways and its role in cancer progression. (2013, background): “This mechanism allows to han nutrient deprivation and therefore by hypoxia/ischemia, oxidative stress, TRAIL andAMPK in several cancermodels [6,44,104,172].”
• Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2012, neutral): “Some other cancer types for which ROS have been shown to effectively induce autophagic cell death are breast cancer (281), nonsmall cell lung cancer (NSCLC) (184), glioma (239, 317), neuroblastoma (317), glioblastoma (53), and cervical cancer (53, 108).”
• Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022, background): “Depending on the nature of the exposure, cells can activate adaptive cell survival pathways; however, chronic exposure or excessively high levels of ROS may result in the induction of maladaptive autophagic or apoptotic pathways [27,28].”