Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy

By A. Hamacher-Brady, N. R. Brady, S. Logue, M. R. Sayen, M. Jinno, L. Kirshenbaum, R. Gottlieb, Åsa B. Gustafsson. Cell Death and Differentiation, 2007

632 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/79f9dc9b4a584ec75ccfcb6b06dc8009872f7467

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Citations in the corpus

Mitochondrial fission and remodelling contributes to muscle atrophy (2010, background): “Bnip3 belongs to BH3-only proteins of bcl2 family and can induce apoptosis as well as mitochondrial fragmentation and mitophagy (Hamacher-Brady et al, 2007).”
Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance (2010, background): “To address this question in a relevant in vivo setting, we set out to introduce a block in autophagy using a dominant-negative form of Atg5 (DN-Atg5) (Hamacher-Brady et al., 2007) in ob/ob mice in which Atg7 expression is also reconstituted in the liver.”
Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “With regard to ATG5, a better approach may be to use a dominant negative (K130R) version.(706,753,754) Along these lines, and as stated above for the use of inhibitors, when employing a knockout or especially a knockdown approach, it is again incumbent upon the researcher to demonstrate that autopha”
Hypoxia and mitochondrial oxidative metabolism. (2010, background): “involved in the regulation of the ageing process and in several human diseases, such as myocardial ischemia/reperfusion [82], Alzheimer's”
ROLE OF BNIP3 AND NIX IN CELL DEATH, AUTOPHAGY, AND MITOPHAGY (2009, neutral): “In an ischemia-reperfusion model, BNIP3 induced autophagy, which protected HL-1 myocytes from cell death.(59) Similarly, hypoxia-induced BNIP3 increased auto-”
Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy* (2012, methodology): “In a previous study from our laboratory, we confirmed that silencing Bnip3 using siRNA or inhibition using a dominant negative Bnip3 reduces autophagy in response to simulated ischemia/ reperfusion (15), suggesting that Bnip3 is responsible for the FIGURE 7.”
Ischemia/Reperfusion (2016, neutral): “postischemic damage and thus is a death modality in I/R (320, 326, 539, 540, 700, 805, 900).”
The Interplay Between Mitochondrial Dynamics and Mitophagy (2011, background): “In HL-1 cells, enhancement of autophagy by overexpressing ATG5 protects against Bnip3-mediated cell death, whereas inhibition of autophagy by ATG5 enhances cell death (37).”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, neutral): “duction offers the possibility of their use in cell culture or in vivo.(1210) However, since autophagy is an essential metabolic process for many cell types and tissues, loss of viabil-”
Mitochondria and Mitophagy: The Yin and Yang of Cell Death Control (2012, background): “is a potent inducer of mitophagy in cells including cardiac myocytes.(8,24) In cells lacking BAX and BAK, overexpression of”
FoxO3 controls autophagy in skeletal muscle in vivo. (2007, background): “We subsequently focused on Bnip3 and Bnip3l, which are among the most induced atrogenes in different types of muscle wasting and have been shown to control autophagy in other cell systems (Hamacher-Brady et al., 2007; Tracy et al., 2007).”