Autophagy-Independent Functions of the Autophagy Machinery

By L. Galluzzi, Douglas R. Green. Cell, 2019

768 citations recorded by the source corpus.

Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism that culminates with the lysosomal degradation of superfluous or potentially dangerous cytosolic entities. Over the past 2 decades, the molecular mechanisms underlying several variants of autophagy have been characterized in detail. Accumulating evidence suggests that most, if not all, components of the molecular machinery for autophagy also mediate autophagy-independent functions. Here, we discuss emerging data on the non-autophagic functions of autophagy-relevant proteins.

Subfields: Epidemiology

View Paper: https://www.semanticscholar.org/paper/d87ff0d2091db8d4fa31749ed88ba6427608090b

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In Epidemiology

1. V. Deretic
2. T. Lamark
3. T. Johansen
4. Beth Levine
5. I. Slaninová
6. N. Mizushima
7. D. Klionsky
8. G. Hotamışlıgil

Citations in the corpus

• Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors. (2020, background): “It should be mentioned that ATG8 family also engage in interactions with LIR-containing proteins in non-autophagic processes too [63,64].”
• Autophagy in inflammation, infection, and immunometabolism (2021, background): “The lysosome and the endosomal system are involved in ‘non-canonical’ autophagy-related processes that utilize portions of the autophagy machinery and affect inflammation (Figure 1B,C) (Galluzzi and Green, 2019).”