Autophagy: from phenomenology to molecular understanding in less than a decade

By D. Klionsky. Nature reviews. Molecular cell biology, 2007

2,000 citations recorded by the source corpus.

Subfields: Epidemiology, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/672621fc26cefb2a937cca8d8deaa94646e51acc

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Citations in the corpus

Dynamics and diversity in autophagy mechanisms: lessons from yeast (2009, background): “jpg" NDATA ITEM> ]> Autophagy (or macroautophagy ) was defined in mammalian cells more than 50 years ago as a system that delivers the cytoplasmic components and organelles of a cell to lysosomes for degradatio”
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster (2010, background): “Inhibition of TOR signaling via TORC1 has pleiotropic effects on cell physiology, including activation of autophagy (Klionsky, 2007), downregulation of cap-dependent protein translation,”
Regulation Mechanisms and Signaling Pathways of Autophagy (2009, background): “Autophagosomes have been observed by electron microscopy in mammalian cells since as early as the 1950s (68), whereas the molecular era of autophagy study began little more than a decade ago, starting primarily from genetic screens in the budding yeast Saccharomyces”
Autophagy: process and function. (2007, background): “Autophagy is a general term for the degradation of cytoplasmic components within lysosomes (Cuervo 2004; Levine and Klionsky 2004; Shintani and Klionsky 2004; Klionsky 2005, 2007; Mizushima and Klionsky 2007).”
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. (2010, positive): “Another mechanism involves activation of macroautophagy (autophagy), a degradation pathway involving delivery of cytoplasmic constituents by double-membrane autophagosomes (AV) that fuse with lysosomal membranes (Klionsky, 2007).”
The regulation of autophagy – unanswered questions (2011, background): “The resulting degradation products are then transported back into the cytosol through the activity of membrane permeases for reuse (Klionsky, 2007) (Fig.”
Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “, breast cancer MDA-MB-231)(57) to investigate the various phases of autophagosome maturation, and to reveal useful details about the origin and evolution of their limiting membranes.(2,8,58-60) The phagophore and the limiting membranes of autophagosomes contain few, or no detectable, IMPs (Fig.”
Deacetylation of nuclear LC3 drives autophagy initiation under starvation. (2015, background): “Autophagy is a self-digestion process in which portions of the cytoplasm, includingproteinaggregatesanddamagedorganelles, are encapsulated by double-membraned structures and delivered to lysosomes for degradation (Klionsky, 2007; Mizushima, 2007; Mizushimaet al., 2010).”
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. (2009, background): “, and Klionsky, D.J. (2008). The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae.”