Autophagy in cell death: an innocent convict?

By Beth Levine, Junying Yuan. Journal of Clinical Investigation, 2005

1,793 citations recorded by the source corpus.

Subfields: Epidemiology, Parasitology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/14947914c548efe7344077a807cb0bcb5335e84f

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Citations in the corpus

Cell death in the nervous system (2006, background): “Nutrient withdrawal inactivates TOR (target of rapamycin), activating an ATG comple”
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria (2010, background): “mechanism, there is much controversy about the functional role of autophagy in life and death.(17,18) Depending on the cellular context, the cell line and the stimulus, autophagy either favors or counteracts cell death signaling.”
Autosis and autophagic cell death: the dark side of autophagy (2014, background): “On the basis of these ultrastructural criteria, autophagic cell death was described during animal development, tissue homeostasis, and in diseased tissues, as well as in cultured mammalian cells treated with chemotherapeutic agents or other toxic compounds.(3) Using more stringent genetic criteria t”
Autophagy, amyloidogenesis and Alzheimer disease (2007, background): “…2003; Anglade et al., 1997; Kadowaki and Kanazawa, 2003; Shigemitsu et al., 1999; Kanazawa et al., 2003), including neurodegenerative diseases (Nixon et al., 2005; Rubinsztein et al., 2005), and is considered to be a neuroprotective response in these states (Levine and Yuan, 2005; Nixon, 2006).”
Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology. (2010, background): “generally accepted in some fields [73] but alternative interpretations have been proposed [74].”
Autophagic cell death: the story of a misnomer (2008, background): “Death effector or corpse remover? It was once postulated that high levels of autophagy might be considered as a 'clean-up' or 'self-clearance' mechanism in cells that are committed to die by apoptosis or necrosi”
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG (2006, background): “are both monoallelically mutated in various human cancers, and autophagy affects tumour development and/or progressio”
Autophagy as a target for anticancer therapy (2011, background): “Conversely, unrestrained autophagy can result in progressive consumption of cellular components and subsequent cell death”
History of lectins: from hemagglutinins to biological recognition molecules. (2004, background): “Overexpression of beclin 1, a protein required for autophagosome formation and recruitment of autophagosome components, in neurons reduced Sindbis virus replication [83], while in cells deprived of beclin 1, Sindbis virus and Herpes simplex virus replicate to higher titers than in wild-type cells [8”
Regulation of autophagy by cytoplasmic p53 (2008, background): “At least one of the phylogenetically conserved autophagy genes, atg6/beclin 1 , is frequently inactivated at one locus in human cancers, and mouse studies have confirmed that beclin 1 is a haploinsufficient tumour suppresso”
Autophagy gene-dependent clearance of apoptotic cells during embryonic development. (2007, background): “Another theory is that autophagy may be activated for cellular autolysis and selfclearance during forms of developmental PCD accompanied by insufficient availability of engulfment cells (Levine and Yuan, 2005; Yuan et al., 2003).”
A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans (2008, background): “In addition to recycling cytoplasmic contents, autophagy is also involved in non-apoptotic, programmed cell death [53].”
Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells (2008, methodology): “Autophagy is characterized by the formation of AVOs (autophagosomes and autolysosomes).(1) AVOs were quantified by flow cytometry after cells were stained by AO.”