The role of autophagy in cancer development and response to therapy

By Y. Kondo, T. Kanzawa, R. Sawaya, S. Kondo. Nature Reviews. Cancer, 2005

1,726 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Geriatrics and Gerontology

View Paper: https://www.semanticscholar.org/paper/cdefa98415b1f072989214b62e51073c82304e33

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In Cell Biology

1. Amy S. Lee
2. Xiaohua Li
3. Asfar S. Azmi
4. J. Chiche
5. Binyun Ma
6. Shi-kun He
7. J. Pouysségur
8. Michael R Hamblin

In Epidemiology

1. Amy S. Lee
2. Xiaohua Li
3. Binyun Ma
4. Shi-kun He
5. Simone Fulda
6. G. Semenza
7. I. Slaninová
8. R. Kaufman

Citations in the corpus

• Cell Death Pathways in Photodynamic Therapy of Cancer (2011, background): “One of the first diseases associated with autophagy was cancer [113].”
• Cancer and Radiation Therapy: Current Advances and Future Directions (2012, background): “With autophagy, the PI3K-Akt-mTOR cascade is thought to be important [55].”
• Tumor resistance to apoptosis (2009, background): “Activation of these nonapoptotic cell death modes presents an alternative approach to induce cell death in apoptosis resistant types of human cancers.(12)”
• The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis (2007, background): “However, prolonged autophagy can lead to non-apoptotic type II programmed cell deat”
• Broad targeting of resistance to apoptosis in cancer (2015, background): “[63] Kondo Y, Kanzawa T, Sawaya R, Kondo S.”
• Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. (2014, result): “This inference is supported by the observation that the more vascular ShhPKCY tumors had a nearly 5-fold decrease in autophagy, a process of cellular autodigestion used by nutrient-deprived cells (Kondo et al., 2005).”
• Mechanisms of Cell Death in Oxidative Stress (2007, neutral): “Thus, recent evidence suggests that PKC isoforms may regulate various aspects of the apoptotic program, however the mechanisms and isoform specificity of these interactions are not completely”
• Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment (2013, background): “The MEK/ERK signaling activation and Rag inactivation contribute to amino acid depletioninduced autophagy.(7,21) Many anticancer drugs including Tumor heterogeneity Drug efflux and metabolism”
• GRP78 induction in cancer: therapeutic and prognostic implications. (2007, background): “ER stress also induces autophagy, a cellular degradation process implicated in both cell death and survival (4).”
• Hypoxia signalling in cancer and approaches to enforce tumour regression (2006, background): “, which is a process commonly induced by hypoxia and representing the ‘ultimate’ nutritional source for tumour cells to survive low-nutrient condition”
• Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains (2009, background): “Autophagy is an evolutionarily conserved mechanism involving the formation of autophagosomes that sequester cytoplasmic macromolecules and organelles before fusion with the endo/lysosomal compartment (13, 34, 35).”
• Autophagy and autophagy-related proteins in cancer (2020, background): “lignant glioma cells [260, 261], Temozolomide (TMZ) in malignant glioma cells [262], γ-irradiation in breast cancer, prostate cancer, colon cancer and malignant glioma [263–265], resveratrol in ovarian cancer [266], TNFα in breast cancer cells [267], IFNγ in Hepatocellular carcinoma (HCC) [268], ima”