FOXO transcription factors at the interface between longevity and tumor suppression

By E. L. Greer, A. Brunet. Oncogene, 2005

1,354 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/ccacc083d098d2ed6cd94e290cc63864fbcea1c1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Brian K. Kennedy
2. David M. Sabatini
3. V. Longo
4. Manuel Serrano
5. D. Sinclair
6. M. Collado
7. F. Alt
8. T. Horvath

In Molecular Biology

1. David M. Sabatini
2. J. Blenis
3. N. Hay
4. D. Guertin
5. Stefanie Dimmeler
6. E. Jacinto
7. A. Zeiher
8. Manuel Serrano

In Physiology

1. David M. Sabatini
2. Manuel Serrano
3. D. Muñoz‐Espín
4. M. Collado
5. N. Hay
6. R. DePinho
7. Brian K. Kennedy
8. V. Longo

Citations in the corpus

• SIRTUIN 1 AND SIRTUIN 3: PHYSIOLOGICAL MODULATORS OF METABOLISM (2012, background): “FOXO proteins are inactivated by the PI3k-Akt/PKB pathway in response to hormonal signaling (32, 120).”
• The Ras-ERK and PI3K-mTOR Pathways: Cross-talk and Compensation (2011, background): “14-3-3 proteins bind the phosphorylated sites and sequester FOXOs in the cytosol, thereby precluding their ability to enter the nucleus and activate quiescence and apoptotic gene expression programs [45].”
• SIRT1 controls endothelial angiogenic functions during vascular growth. (2007, background): “Foxo transcription factors are important targets for SIRT1-dependent deacetylation (Greer and Brunet 2005), and SIRT1 has been shown to tip the balance of Foxo functions away from cell death toward stress resistance (Brunet et al. 2004; Motta et al. 2004).”
• An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “These proteins are ubiquitous in eukaryotic cells and thought to be critical in regulating cell cycle arrest, cellular stress responses, apoptosis, and longevity (86).”
• From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. (2010, neutral): “In Downloaded from https://academic.oup.com/edrv/article-abstract/31/3/266/2354731 by guest on 26 July 2018 mammals, this subclass comprises four members: FoxO1 (or FKHR), FoxO3 (or FKHRL1), FoxO4 (also called AFX), and FoxO6 (55).”
• SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. (2006, background): “…at multiple sites including Thr24 has been proposed to promote the nuclear exclusion and binding to 14-3-3 proteins of FoxOs (Barthel et al., 2005; Greer and Brunet, 2005), a fully active, doubly phosphorylated Akt may enhance or sustain inhibition of these transcription factors to promote cell…”
• ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation (2008, background): “FOXO transcription factors, one of large forkhead family members, include FOXO1, FOXO3, FOXO4 and FOXO6 (ref”
• FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis (2009, background): “On the basis of the fact that FoxOs had been reported to influence each of these processes in other systems (reviewed in Greer and Brunet, 2005), and the importance of the FoxOs in the maintenance of HSC reserves (Miyamoto et al., 2007; Tothova et al., 2007), and finally the highly cell…”
• Redox regulation of FoxO transcription factors (2015, background): “2), FoxO1a, FoxO3a, FoxO4 and FoxO6 (for an overview on FoxO nomenclature, see [13]).”
• Sirtuins in aging and age-related disease. (2006, background): “Sirt1 deacetylation can either lead to activation or repression of FOXO-dependent transcription depending on the context (Greer and Brunet, 2005).”