Sirtuins in aging and age-related disease.

By V. Longo, Brian K. Kennedy. Cell, 2006

643 citations recorded by the source corpus.

Subfields: Epidemiology, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/99f9b96395c8c2fd567a92df559f02ad7bdfc86f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Matt Kaeberlein
2. G. Shadel
3. L. Guarente
4. M. Haigis
5. Brian K. Kennedy
6. V. Longo
7. E. Verdin
8. F. Alt

In Geriatrics and Gerontology

1. L. Guarente
2. M. Haigis
3. E. Verdin
4. V. Longo
5. Brian K. Kennedy
6. R. Mostoslavsky
7. Matt Kaeberlein
8. M. McBurney

In Physiology

1. E. Verdin
2. L. Guarente
3. M. Haigis
4. Brian K. Kennedy
5. V. Longo
6. R. Mostoslavsky
7. Matt Kaeberlein
8. F. Alt

Citations in the corpus

• Replicative and Chronological Aging in Saccharomyces cerevisiae (2012, positive): “These results indicate that the effects of Sir2 on CLS are complex and raise the interesting possibility that Sir2 could both interfere with and promote the beneficial effects of CR (Longo and Kennedy, 2006).”
• SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation (2012, positive): “The chromatin silencing factor Sir2 (silent information regulator-2) catalyses NAD 1 -dependent histone deacetylation to regulate genomic stability and cellular senescence in budding yeast 1,2 .”
• Sirtuins: critical regulators at the crossroads between cancer and aging (2007, background): “Members of the silent information regulator 2 (Sir2) family, which are conserved from bacteria to humans, regulate lifespan in various organisms (Longo and Kennedy, 2006).”
• Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation (2007, background): “It has been proposed that sirtuins mediate the longevity-promoting effects of calorie restriction (CR) in yeast, worms, flies, and mice (4, 17, 22, 24).”
• Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. (2008, background): “…IH -PA Author M anuscript While their role on lifespan is still a matter of intense debate (Chen and Guarente, 2007; Kaeberlein and Powers, 2007; Longo and Kennedy, 2006; Michan and Sinclair, 2007), it is well established that the sirtuins- a family of evolutionarily conserved deacetylases -…”
• The Histone Deacetylase SIRT6 Regulates Glucose Homeostasis via Hif1α (2010, neutral): “In yeast, the founding member of the sirtuin family, Sir2, was originally discovered as a silencing factor, functioning as a sensor of the metabolic activity of the cell to influence gene transcription, DNA repair, recombination, and life span (Haigis and Guarente, 2006; Longo and Kennedy, 2006).”