Redox regulation of FoxO transcription factors
By L. Klotz, Cristina Sánchez-Ramos, Ignacio Prieto-Arroyo, P. Urbánek, H. Steinbrenner, M. Monsalve. Redox Biology, 2015
691 citations recorded by the source corpus.
Transcription factors of the forkhead box, class O (FoxO) family are important regulators of the cellular stress response and promote the cellular antioxidant defense. On one hand, FoxOs stimulate the transcription of genes coding for antioxidant proteins located in different subcellular compartments, such as in mitochondria (i.e. superoxide dismutase-2, peroxiredoxins 3 and 5) and peroxisomes (catalase), as well as for antioxidant proteins found extracellularly in plasma (e.g., selenoprotein P and ceruloplasmin). On the other hand, reactive oxygen species (ROS) as well as other stressful stimuli that elicit the formation of ROS, may modulate FoxO activity at multiple levels, including posttranslational modifications of FoxOs (such as phosphorylation and acetylation), interaction with coregulators, alterations in FoxO subcellular localization, protein synthesis and stability. Moreover, transcriptional and posttranscriptional control of the expression of genes coding for FoxOs is sensitive to ROS. Here, we review these aspects of FoxO biology focusing on redox regulation of FoxO signaling, and with emphasis on the interplay between ROS and FoxOs under various physiological and pathophysiological conditions. Of particular interest are the dual role played by FoxOs in cancer development and their key role in whole body nutrient homeostasis, modulating metabolic adaptations and/or disturbances in response to low vs. high nutrient intake. Examples discussed here include calorie restriction and starvation as well as adipogenesis, obesity and type 2 diabetes.
Subfields: Aging, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/71e51def596a1bef43b645d7f296804579613691
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Aging
In Molecular Biology
Citations in the corpus
- ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases (2016, background): “FOXO3A Cell coordination in response to OS [51] Metabolic adaptation to low nutrient intake [73] Cancer development [73] Diabetes [74] Atherosclerotic cardiovascular disease [75]”
- Oxidative Stress in Cancer (2020, background): “They augment antioxidant status by inducing genes that eliminate ROS and improve mitochondrial redox and suppress levels of free transition metal ions by increasing levels of metallothionein and ceruloplasmin (Klotz et al., 2015).”