Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node

By Mark J. Miller, Sindy H. Wei, I. Parker, M. Cahalan. Science, 2002

1,246 citations recorded by the source corpus.

Subfields: Immunology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/cca7867741bd181ae30cf41b9bad00f1e7703ed7

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In Immunology

In Immunology and Allergy

Citations in the corpus

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice (2006, background): “Other TPLSM studies have shown the highly dynamic nature of T cell activity in antigen-draining lymph nodes after exposure of mice to nominal antigen in adjuvant- or antigen-pulsed mature DC”
FOLLICULAR HELPER T CELLS: LINEAGE AND LOCATION (2009, background): “Real-time imaging with two-photon laser scanning technology has provided outstanding clarity to these early cellular interactions in vivo (Miller et al., 2002).”
Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. (2004, background): “Similarly, T cells that home into LNs display chemokinesis when viewed both by multiphoton microscopy in freshly excised LNs in vitro and by intravital microscopy in vivo (202, 203).”
Intracellular signalling controlling integrin activation in lymphocytes (2005, methodology): “Recent in situ -imaging techniques, such as MULTI-PHOTON MICROSCOPY , have revealed robust interstitial migration of naive lymphocytes in peripheral lymph node”
The who, how and where of antigen presentation to B cells (2009, methodology): “The earliest multiphoton microscopy investigations were carried out on explanted or isolated lymph node”
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76 (2005, neutral): “Immunological synapse structure is maintained for hour”
T-cell-antigen recognition and the immunological synapse (2003, background): “In one study, T cells moved rapidly and formed few stable contacts in tissue perfused with 100% oxyge”
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases (2004, background): “Because lymphocytes continually enter and leave normal LNs, the resident lymphocyte pool is composed of non-synchronized cells with different dwell times that display heterogeneous behaviour in mouse LNs in vitro”
Translating innate immunity into immunological memory: implications for vaccine development. (2006, positive): “Furthermore, mature DCs extend many long dendrites, which can cover a considerable volume, thus enhancing the potential zone of DC-T cell contacts, as demonstrated by elegant studies using two-photon laser scanning microscopy (Miller et al., 2002).”