Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76

By T. Yokosuka, K. Sakata-Sogawa, Wakana Kobayashi, M. Hiroshima, A. Hashimoto-Tane, M. Tokunaga, Michael Loran Dustin, T. Saito. Nature Immunology, 2005

749 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/c9c8d9b70e605775cbcd026f2a1d5bd879edb231

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In Immunology

1. Michael Loran Dustin
2. J. Orange
3. H. Schneider
4. Alison Taylor
5. C. E. Rudd
6. M. Azuma

Citations in the corpus

• The Immunological Synapse (2014, background): “dSMAC and move centripetally through the pSMAC to the cSMAC (111, 113, 126).”
• Adhesion of membranes via receptor-ligand complexes: Domain formation, binding cooperativity, and active processes (2009, background): “[89, 90], the inequality (17) also helps to understand the joint role of foreign and self MHC-peptides in T-cell activation.”
• T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. (2006, methodology): “Results TCR Microclusters Join to Form the cSMAC Signaling is initiated and sustained in TCR microclusters that are formed continuously in the periphery of the IS and transported to the center to form the cSMAC (Campi et al., 2005; Yokosuka et al., 2005).”
• Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2 (2012, background): “…we and others have revised this idea and proposed that T cell activation is induced by a minimal T cell activation unit, the TCR microcluster, which consists of TCRs and their proximal signaling molecules (Bunnell et al., 2002; Campi et al., 2005; Yokosuka et al., 2005; Yokosuka and Saito, 2010 ).”
• Formation and function of the lytic NK-cell immunological synapse (2008, background): “or the involvement of microclusters of cell-surface and signalling molecules can support cell activation without the need for a mature synaps”
• CD28 and CTLA-4 coreceptor expression and signal transduction (2009, background): “Gads and SLP-76), while other complexes carrying ZAP-70 can transiently interact with the TCR or SLP-76 clusters (164, 165).”