T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

By T. Mempel, S. Henrickson, Ulrich H. von Andrian. Nature, 2004

1,831 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2346753de3fd8563deaa274c0e1724846d06a396

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In Immunology

Citations in the corpus

Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy (2017, result): “The measured velocity in BP-SIY tumors is consistentwith published rates for settings inwhichTCRengagementby antigen generates T cell slowing (Mempel et al., 2004).”
Antigen-Engaged B Cells Undergo Chemotaxis toward the T Zone and Form Motile Conjugates with Helper T Cells (2005, methodology): “Interfollicular regions are also rich in high endothelial venules, and other studies have indicated that DCs newly arriving in lymph nodes are often found near follicles or clustered around high endothelial venules [14,17,54], and small, soluble antigens can reach these regions via conduits that con”
CD8+ T Cells: Foot Soldiers of the Immune System (2011, neutral): “Subsequent to injection of peptide-loaded dendritic cells (DCs), T cells scan the HEV-asso-ciated DC forming antigen-speciﬁc contacts with the DCs, leading to T cell activation (Bousso and Robey, 2003; Mempel et al., 2004; Miller et al., 2003).”
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells for immune T cell areas (2010, background): “However, 12 hr after LPS i.v., DC-SIGN+ cells were abundant and localized to T cell areas, regions in which DCs have been shown to present antigens to recirculating antigenspecific T cells (Stoll et al., 2002; Mempel et al., 2004; Miller et al., 2004; Shakhar et al., 2005) (Figure 2C).”
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2 (2012, background): “There appears to be a stepwise interaction between the two cells, ranging from transient contact to a stable interaction with synapse formation (Mempel et al., 2004).”