Toll-like receptor 2 controls expansion and function of regulatory T cells.

By R. Sutmuller, M. D. den Brok, Matthijs Kramer, E. Bennink, L. W. Toonen, B. Kullberg, L. Joosten, Shizuo Akira, Mihai G. Netea, G. Adema. Journal of Clinical Investigation, 2006

820 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/cbe43ddccf4edf350ede9f1341fea9edab1b0195

How researchers see this paper

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In Immunology

1. Shizuo Akira
2. Taro Kawai
3. Luke A. O'Neill
4. B. Guy
5. A. Sher
6. Mihai G. Netea
7. G. Trinchieri
8. R. Medzhitov

Citations in the corpus

• Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota (2010, background): “Our findmgs are entIrely consistent With reports that TLR2- - mice have defects in Foxp3 + Treg cells (24, 25).”
• Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. (2011, background): “TLR2-deficient mice are more resistant to lethal disseminated candidiasis than control mice, and this is accompanied by decreased production of IL-10 and increased production of IFN-g and IL-12 (Netea et al., 2004; Sutmuller et al., 2006).”
• Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders (2010, background): “Currently we are trying to identify and elucidate the role of the pattern recognition receptors (e.g., Toll-like receptor-2 and other TLRs) (25, 26) and underlying signal transduction pathways (e.g., Myd88 dependency).”
• Regulatory T cells and infection: a dangerous necessity (2007, background): “Natural T Reg cells have been shown to be controlled directly or indirectly by Toll-like receptor (TLR) signalling (reviewed in Ref”
• The immunology of sepsis (2008, background): “TLR activation can also act directly on T cells mediating a number of effects, including the expansion of regulatory T cells (Tregs) [9].”
• An integrated model of the recognition of Candida albicans by the innate immune system (2008, background): “albicans induces immunosuppression through TLR2-mediated IL-10 release, and this leads to the generation of CD4 + CD25 + T Reg cells with immunosuppressive potentia”
• Resolution of inflammation: state of the art, definitions and terms (2006, background): “Another example concerns regulatory T cells (T regs) (18, 19).”
• The perfect mix: recent progress in adjuvant research (2007, background): “The consequence of direct stimulation is to activate T Reg cells, as has been shown, for example, for TLR2 and TLR4 (Ref”
• The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress (2008, background): “TLR2 in particular has been shown to be expressed on regulatory T cells, and TLR2 can control their expansion and function (34).”
• Cooperation of Toll-like receptor signals in innate immune defence (2007, background): “For example, Tlr2 −/− mice have been reported to be deficient in CD4 + CD25 + regulatory T (T Reg ) cells and ligation of TLR2 on adoptively transferred T Reg cells impairs their suppressive function in vivo , resulting in increased resistance to Candida albicans infectio”