Resolution of inflammation: state of the art, definitions and terms
By Charles N Serhan, S. Brain, C. Buckley, D. Gilroy, C. Haslett, Luke A. J. O’Neill, M. Perretti, Adriano G. Rossi, John L Wallace. The FASEB Journal, 2006
1,146 citations recorded by the source corpus.
A recent focus meeting on Controlling Acute Inflammation was held in London, April 27–28, 2006, organized by D.W. Gilroy and S.D. Brain for the British Pharmacology Society. We concluded at the meeting that a consensus report was needed that addresses the rapid progress in this emerging field and details how the specific study of resolution of acute inflammation provides leads for novel anti‐inflammatory therapeutics, as well as defines the terms and key components of interest in the resolution process within tissues as appreciated today. The inflammatory response protects the body against infection and injury but can itself become dysregulated with deleterious consequences to the host. It is now evident that endogenous biochemical pathways activated during defense reactions can counter‐regulate inflammation and promote resolution. Hence, resolution is an active rather than a passive process, as once believed, which now promises novel approaches for the treatment of inflammation‐associated diseases based on endogenous agonists of resolution.—Serhan, C. N., Brain, S. D., Buckley, C. D., Gilroy, D. W., Haslett, C., O'Neill, L. A. J., Perretti, M., Rossi, A. G., Wallace, J. L. Resolution of inflammation: state of the art, definitions and terms. FASEB J. 21, 325–332 (2007)
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/95201249b0b431ac91b296ca9d800a148b3fa66a
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
In Molecular Biology
Citations in the corpus
- Transition from inflammation to proliferation: a critical step during wound healing (2016, background): “, dissipation of chemotactic gradient or initial danger signals, but also active biochemical pathways [103].”
- Role of Inflammation in Diabetic Retinopathy (2018, background): “Inflammati normally resolves pro ptly through a coordinated program that includes resolvins, lipoxins and protectins [42].”
- Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators. (2018, background): “, disrupting active resolution programs (20) including NSAIDs and COX-2 inhibitors.”
- Homeostasis, Inflammation, and Disease Susceptibility (2015, neutral): “The non-resolving inflammation may, in turn, account for the persistence of chronic diseases (Nathan and Ding, 2010; Serhan et al., 2007).”
- Cytokines and their relationship to the symptoms and outcome of cancer (2008, background): “A disturbed balance between pro- and anti-inflammatory mechanisms leads to chronic immune activation and inflammatio”
- Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself? (2008, background): “PGD2 metabolites, including 15-deoxy 12-14 PGJ2, also derived from COX-2, have been implicated as key mediators of the resolution of inflammation in various tissues (58, 160).”
- Monocyte-Macrophages and T Cells in Atherosclerosis (2017, positive): “In normal physiology, the inflammatory response is directly linked to a resolution phase that repairs collateral damage and restores tissue homeostasis (Serhan et al., 2007; Nathan and Ding, 2010).”
- Inflammatory and immune pathways in the pathogenesis of periodontal disease (2014, neutral): “nonsteroidal anti-inflammatory drugs) (214).”
- Annexin A1 and glucocorticoids as effectors of the resolution of inflammation (2009, background): “The concept that inflammation is resolved in a time- and space-specific manner is emerging, such that different outcomes can be produced according to the stage or site at which a given pathway or mediator becomes operativ”