Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

By June L. Round, S. Mazmanian. Proceedings of the National Academy of Sciences of the United States of America, 2010

2,212 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9fa7e22877fc59075b8d0b255ec51c494062f8c3

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Citations in the corpus

The immune system and the gut microbiota: friends or foes? (2010, background): “fragilis , but not by a mutant strain that lacks PSA, protected mice from the severe experimental colitis that is induced by Helicobacter hepaticus”
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells (2012, background): “In fact, it has recently been shown that components of the gut commensal microbiota can direct conversion of naive T cells to iT reg cells, and that some iT reg cells recognize microbiota antigens (Round and Mazmanian, 2010; Atarashi et al., 2011; Lathrop et al., 2011).”
Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection (2012, methodology): “Colon Lamina Propria Lymphocyte Isolation and Intracellular Cytokine Staining Performed as previously described (Round et al., 2011; Round and Mazmanian, 2010).”
Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn's disease (2015, background): “fragilis-derived polysaccharide A, have previously been demonstrated to have immunomodulatory functions [47] [48] [49].”
The Human Microbiome: at the interface of health and disease (2012, background): “, and polysaccharide A produced by Bacteroides fragilis mediates the conversion of CD4 + T cells into regulatory T cell”
Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice (2017, background): “This recalls previous reports describing enhanced IL10 production in the intestinal immune system driven by bacterial polysaccharide A (33) and protection from actively induced CNS autoimmune disease (34).”
Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models (2017, neutral): “However, it is equally important to investigate how variability in microbial abundance and composition affects host functions (2, 3).”