Cooperation of Toll-like receptor signals in innate immune defence

By G. Trinchieri, A. Sher. Nature reviews. Immunology, 2007

1,455 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a4b081252abcf395a1a9ba0daaf4f285b2c8dbe6

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Citations in the corpus

Mast cell-orchestrated immunity to pathogens (2010, background): “This can be achieved by directly recognizing pathogens through pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs), which are activated in response to conserved pathogen-associated molecular patterns (PAMPs”
The neuropathic pain triad: neurons, immune cells and glia (2007, background): “Mammalian Toll-like receptors (TLRs) are a family of twelve evolutionarily conserved membrane proteins that are fundamental in the initiation of innate immunity against invading pathogen”
CD4+T Cells: Differentiation and Functions (2012, background): “IL12 is secreted in large amounts by APCs after their activation through the pattern recognition receptors [14, 15, 20].”
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17 (2007, background): “IL-12p35 production is regulated at many levels and is strongly enhanced by synergistic interaction between different TLRs, costimulation by IFN-γ or CD40 ligand, or type I interferon receptor signalin”
Microglia: active sensor and versatile effector cells in the normal and pathologic brain (2007, background): “For example, the families of pattern recognition receptors, such as Toll-like receptors (TLRs), detect and differentiate viral, bacterial and fungal structures [10, 11 ].”
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome (2009, background): “The best described class of these receptors are Toll-like receptors (TLRs), which predominantly sense pathogenassociated molecular patterns (PAMPs) (2).”
Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity (2008, background): “Recognition of, and response to, pathogen-associated molecular patterns (PAMPs), which are structures on the pathogen that can trigger innate immune responses, are mediated via a broad spectrum of immune surveillance proteins such as the Toll-like receptors (TLRs)—an extended family of host noncatal”
Apoptosis: controlled demolition at the cellular level (2008, background): “Stimulation of pattern-recognition receptors on cells of the innate immune system, particularly dendritic cells, equips these cells with the ability to activate T cells productively and to initiate immune response”
Macrophage activation by endogenous danger signals (2008, background): “The TLRs are the most well-characterized PRRs and, because these receptors play a major role in the recognition of both endogenous as well as exogenous stimuli [23], their biology will be briefly reviewed.”
Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens (2010, background): “Therefore, a broader holistic view of how MAMPs and PRRs are represented on the bacterial and host cells, respectively, is neede”
The Multifaceted Functions of Neutrophils (2013, background): “Expression profiling of TANs in mouse models confirms that mRNAs for various chemokines are significantly (>75- fold) increased (240).”
The role of oxidative stress during inflammatory processes (2013, background): “Sensing of PAMPs and DAMPs is ensured by a complex set-up of PRRs, which include primarily the Toll-like receptors (TLRs) (Trinchieri and Sher, 2007) and the nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) (Martinon et al., 2009).”