An integrated model of the recognition of Candida albicans by the innate immune system

By Mihai G. Netea, Gordon D. Brown, B. Kullberg, N. Gow. Nature Reviews Microbiology, 2008

941 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/8f6d50a5218c8de1a813e92a986cd56c1ddca6bb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Mihai G. Netea
2. Y. Iwakura
3. Ramnik J. Xavier
4. H. Ishigame
5. Shizuo Akira
6. Taro Kawai
7. R. Medzhitov

In Immunology

1. Mihai G. Netea
2. L. Oliveira-Nascimento
3. P. Massari
4. L. Wetzler
5. L. Joosten
6. Y. Iwakura
7. C. Lowell
8. T. Mayadas

In Infectious Diseases

1. Mihai G. Netea
2. Shizuo Akira

Citations in the corpus

• Candida albicans morphogenesis and host defence: discriminating invasion from colonization (2011, neutral): “The cell wall therefore represents an ideal immunological target to discriminate self from non-self, and consequently the majority of fungal PAMPs (pathogen-associated molecular patterns) that activate and modulate immune responses are cell wall component”
• The Role of TLR2 in Infection and Immunity (2012, background): “The shielding of β-glucans can impair Dectin-1 recognition and consequent loss of synergy with TLR2, which allows for a preferential induction of an anti-inflammatory response when stimulated by fungal particles (Netea et al., 2008).”
• The Multifaceted Functions of Neutrophils (2013, background): “Although studies in neutrophils of these patients are not comprehensive, mice deficient in these molecules have defects in neutrophil cytotoxic responses (70, 145).”
• Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. (2010, background): “a-(1, 2) / (1, 3)-mannose of N-linked mannans, DC-SIGN (SIGNR-1, CD209a) recognizes branched a-mannans, and Galectin-3 recognizes b-(1, 2)-mannans (Netea et al., 2008; Poulain and Jouault, 2004).”
• Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes (2012, background): “Only a partial inhibition of the training of monocytes was observed when the CR3 receptor was blocked (Figure 3B).”
• How microorganisms use hydrophobicity and what does this mean for human needs? (2014, background): “Hydrophilic cells have an elongated acid-labile mannan fraction in the cell wall and the length of this structure affects the folding of cell wall fibrils and the cell surface hydrophobicity (Netea et al., 2008) (Table 1).”