Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders
By Ho-Keun Kwon, Choong-Gu Lee, Jae-Seon So, Chang-Suk Chae, Ji-sun Hwang, Anupama Sahoo, J. Nam, J. Rhee, K. Hwang, S. Im. Proceedings of the National Academy of Sciences of the United States of America, 2010
620 citations recorded by the source corpus.
The beneficial effects of probiotics have been described in many diseases, but the mechanism by which they modulate the immune system is poorly understood. In this study, we identified a mixture of probiotics that up-regulates CD4+Foxp3+ regulatory T cells (Tregs). Administration of the probiotics mixture induced both T-cell and B-cell hyporesponsiveness and down-regulated T helper (Th) 1, Th2, and Th17 cytokines without apoptosis induction. It also induced generation of CD4+Foxp3+ Tregs from the CD4+CD25− population and increased the suppressor activity of naturally occurring CD4+CD25+ Tregs. Conversion of T cells into Foxp3+ Tregs is directly mediated by regulatory dendritic cells (rDCs) that express high levels of IL-10, TGF-β, COX-2, and indoleamine 2,3-dioxygenase. Administration of probiotics had therapeutical effects in experimental inflammatory bowel disease, atopic dermatitis, and rheumatoid arthritis. The therapeutical effect of the probiotics is associated with enrichment of CD4+Foxp3+ Tregs in the inflamed regions. Collectively, the administration of probiotics that enhance the generation of rDCs and Tregs represents an applicable treatment of inflammatory immune disorders.
Subfields: Dermatology, Immunology
View Paper: https://www.semanticscholar.org/paper/7e0d20f947229462004047a0c4fd7faf409b582e
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Citations in the corpus
- Probiotics and immunity (2009, background): “Thus, probiotics that enhance the generation of regulatory dendritic cells to induce Tregs, represent a potential therapeutic approach for inflammatory disorders [50, 54].”
- Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa (2011, background): “Moreover, a mixture of probiotic strains that elicit high IL-10/IL-12 ratios in vitro expands the T Reg population in the mesenteric lymph nodes in mic”
- Probiotics and the gut microbiota in intestinal health and disease (2010, background): “Some probiotic strains induce regulatory dendritic cells to promote CD4 + FoxP3 + T REG cells to home to the site of inflammation, triggering an anti-inflammatory, regulatory immune response”
- Mechanisms of Action of Probiotics. (2019, background): “(129) identified a mixture of probiotics that upregulates CD4+forkhead box P3 (FoxP3)+ T-regs.”
- Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body (2021, background): “A probiotic mixture engagement with regulatory CD11+ DC enhances Treg cells rising the levels of TGF-b, IL-10, cyclooxygenase-2 (COX-2) and suppress the production of proinflammatory IL-17, IFN-g, and TNF-a (83).”