Identification of a cold receptor reveals a general role for TRP channels in thermosensation

By D. McKemy, W. Neuhausser, D. Julius. Nature, 2002

2,568 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/cac8ce1d499b632ccbc05cfe4d6f6f12d7873e7a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Ardem Patapoutian
2. D. Julius
3. Clifford J. Woolf
4. S. Waddell
5. C. Montell
6. B. Nilius
7. A. Dhaka
8. G. Owsianik

In Molecular Biology

1. D. Julius
2. D. Clapham
3. Ardem Patapoutian
4. C. Montell
5. B. Nilius
6. G. Owsianik
7. D. McKemy
8. H. Chuang

In Sensory Systems

1. D. Julius
2. Ardem Patapoutian
3. Clifford J. Woolf
4. B. Nilius
5. G. Owsianik
6. C. Montell
7. D. Clapham
8. A. Dhaka

Citations in the corpus

• Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels (2006, background): “1 ), whereas menthol activates TRPM8 to produce a 'cooling' sensatio”
• Pathophysiology of Migraine: A Disorder of Sensory Processing. (2017, background): “While LRP1 encodes a lipoprotein involved in nociceptive glutamatergic signaling (147), TRPM8 encodes a cold-sensitive calcium channel that may induce burning pain (84, 592, 656).”
• TFOS DEWS II pain and sensation report (2017, neutral): “TRPM8 is a cation channel that is activated by cooling and menthol and is important for cold sensation [98,106,107], including cold pain [108].”
• An introduction to TRP channels. (2006, background): “TRPM8 is expressed in sensory neurons, in which it may function as a cold thermosensor (161, 162).”
• The TRP Superfamily of Cation Channels (2005, background): “TRPM8 is a “thermoTRP,” which is activated by moderately cool temperatures and by chemicals, such as menthol and icilin, that evoke the sensation of thermal coolness (177, 178).”
• TRP channels as cellular sensors (2003, background): “Its sensory role was recognized when it was isolated by expression cloning of a menthol receptor from trigeminal neuron”
• Membrane fluidity and its roles in the perception of environmental signals. (2004, background): “In the mammalian nervous system, Ca-permeable channels have been identified as cold sensors [92–96].”
• TRP channels and pain. (2013, background): “Like TRPV1, TRPM8 forms a homotetrameric nonselective cation channel with substantial permeability to calcium ions (McCoy et al. 2011, McKemy et al. 2002, Peier et al. 2002, Yudin & Rohacs 2012).”
• The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels (2004, background): “TRPM8 and TRPA1 (ANKTM1) are activated by cooling, (”
• TRP Channels (2012, neutral): “(MCOLN1).”
• The cell biology of taste (2010, background): “Capsaicin (the active compound in chilies) and menthol prin cipally stimulate ion channels in somato sensory nerve fibers (Caterina et al., 1997; McKemy et al., 2002).”
• The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept (2007, background): “Cold-responsive TRP channels include TRPM8 and TRPA1 (Ref”
• Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors (2005, background): “On the other hand, some A-fiber neurons possess TrkB or TrkC, the receptor tyrosine kinases for brainderived neurotrophic factor (BDNF) and neurotrophin (NT)-3, respectively (McMahon et al., 1994).”
• ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. (2003, background): “ANKTM1 belongs to the superfamily of of TRPM8 and TRPV1 (Mckemy et al., 2002; Reid et al., TRP channels, as does the menthol- and cold-activated 2002).”
• A neural circuit mechanism integrating motivational state with memory expression in Drosophila (2009, background): “The mammalian TRPM8 channel is activated below 18 C (McKemy et al., 2002; Peier et al., 2002).”
• TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. (2006, positive): “TRPM8 is activated by cool temperatures and by chemicals such as menthol and icilin that feel cool when applied to the skin (McKemy et al., 2002; Peier et al., 2002).”