TRP Channels

By M. Gees, G. Owsianik, B. Nilius, T. Voets. Comprehensive Physiology, 2012

1,113 citations recorded by the source corpus.

TRP channels constitute a large superfamily of cation channel forming proteins, all related to the gene product of the transient receptor potential (trp) locus in Drosophila. In mammals, 28 different TRP channel genes have been identified, which exhibit a large variety of functional properties and play diverse cellular and physiological roles. In this article, we provide a brief and systematic summary of expression, function, and (patho)physiological role of the mammalian TRP channels. © 2012 American Physiological Society. Compr Physiol 2:563‐608, 2012.

Subfields: Molecular Biology, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/2d6d3a0cfb1efb2757702713c5b348b1d0b1701b

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In Molecular Biology

1. Jian‐Kang Zhu
2. R. Chovatiya
3. G. Owsianik
4. Lizhong Xiong
5. B. Nilius
6. D. Julius
7. R. Medzhitov
8. Yiting Shi

In Nutrition and Dietetics

1. G. Owsianik
2. R. Chovatiya
3. D. Julius
4. B. Nilius
5. R. Medzhitov

In Sensory Systems

1. G. Owsianik
2. B. Nilius
3. R. Medzhitov
4. D. Julius
5. R. Chovatiya
6. Clifford J. Woolf
7. Ardem Patapoutian
8. D. Clapham

Citations in the corpus

• Plant abiotic stress response and nutrient use efficiency (2020, background): “Transient receptor potential vanilloid channels (TRPVs) have been reported to sense temperature signals in mammalian cells (Venkatachalam and Montell, 2007), but no homologs of such receptors have been identified in land plants.”
• The transient receptor potential family of ion channels (2011, background): “The numbers correspond to proteins with distinct channel properties within each subfamily [104-106].”
• TRP channels and pain. (2013, background): “Although TRP channels are widely divergent in their primary structures and (known or presumed) physiologic functions, many resemble ancestral fly channels in their ability to be activated or modulated by PLC-coupled receptors (Venkatachalam & Montell 2007).”
• Stress, Inflammation, and Defense of Homeostasis (2014, background): “Similarly, sensory neurons are specialized in sensing various stressors including cold and hot temperature, reactive chemicals, low pH, etc., through the use of molecular sensors such as TRP and ASIC channels (Venkatachalam and Montell, 2007).”
• Plant essential oils and formamidines as insecticides/acaricides: what are the molecular targets? (2011, background): “Two subfamilies constitute group 2, i.e., TRPP ( “ P ” for polycystic) and TRPML ( “ ML ” for mucolipin; for a review, see Venkatachalam and Montell 2007).”