The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

By T. Voets, G. Droogmans, U. Wissenbach, Annelies Janssens, V. Flockerzi, B. Nilius. Nature, 2004

1,022 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/5c88f3f49b654fc890599e673a009ce4f3d6a559

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. B. Nilius
2. D. Julius
3. G. Owsianik
4. D. Clapham
5. Ardem Patapoutian
6. C. Montell
7. Ellen A. Lumpkin
8. M. Caterina

In Nutrition and Dietetics

1. Ardem Patapoutian
2. B. Nilius
3. G. Owsianik
4. D. Julius
5. Veena Viswanath
6. M. Caterina

In Sensory Systems

1. Ardem Patapoutian
2. D. Julius
3. B. Nilius
4. G. Owsianik
5. D. Clapham
6. C. Montell
7. Veena Viswanath
8. A. Dhaka

Citations in the corpus

• Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress (2008, neutral): “…time-dependent growth at positive membrane potentials and subsequent deactivation on hyperpolarization has been reported for TRPV1 and TRPM8 in the absence of any added agonists as well in the presence of their respective agonists, capsaicin and menthol (Voets et al., 2004; Nilius et al., 2005).”
• Abiotic Stress in Plants; Stress Perception to Molecular Response and Role of Biotechnological Tools in Stress Resistance (2021, background): “Temperature elevation results in depolarization and induces the removal of corresponding neurons [108,109].”
• PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain (2005, background): “Here, we demonstrate a central role for phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) in the activation of recombinant TRPM8 channels by both cold and menthol.”
• TRP channels and pain. (2013, background): “Some TRP channels exhibit a degree of voltage sensitivity, and thermal stimuli may elicit gating by shifting their voltage-dependent activation curves toward physiologic membrane potential (Voets et al. 2004).”
• The TRP Superfamily of Cation Channels (2005, background): “Activation of both of these channels by temperature involves changes in the voltage-dependent activation curves by temperature (179, 180).”
• An introduction to TRP channels. (2006, background): “Channel agonists (cold, menthol, icilin) shift the voltage dependence of TRPM8 to more negative (physiologically relevant) potentials, similar to the shift in voltage dependence seen for TRPV1 (20, 71, 163, 164).”
• The transient receptor potential family of ion channels (2011, background): “or changes in temperature that can alter the midpoint of the activation by several hundreds of millivolts [59,61].”
• Trp ion channels and temperature sensation. (2006, background): “Voets et al. (2004) used a simple twostate (closed-open) model and found that the opening rate of TRPV1 is steeply temperature dependent (Q10 of 14.8), whereas its closing rate has shallow temperature dependence (Q10 of 1.3) (i.e., TRPV1 opens more frequently in hot temperatures).”
• Mechanisms of sensory transduction in the skin (2007, background): “Moreover, thermodynamics-based efforts have yielded some insight into thermosensitivit”
• TRP Channels (2012, neutral): “(B) Steady-state activation curves at different temperatures for the currents shown in A (447).”