ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.

By G. M. Story, A. Peier, A. Reeve, S. R. Eid, J. Mosbacher, Todd Hricik, Taryn J. Earley, A. C. Hergarden, D. Andersson, S. Hwang and 4 more. Cell, 2003

2,465 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/f966f2bef596edabcf7e33ee77c2c1cc03d3e5e3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. D. Julius
2. Ardem Patapoutian
3. Clifford J. Woolf
4. C. Montell
5. B. Nilius
6. A. Dhaka
7. D. Bautista
8. G. Owsianik

In Molecular Biology

1. D. Julius
2. D. Clapham
3. Ardem Patapoutian
4. A. Basbaum
5. C. Montell
6. B. Nilius
7. G. Owsianik
8. D. McKemy

In Sensory Systems

1. D. Julius
2. Ardem Patapoutian
3. Clifford J. Woolf
4. B. Nilius
5. D. Bautista
6. D. Clapham
7. A. Dhaka
8. G. Owsianik

Citations in the corpus

• TRP channels and pain. (2013, background): “AND INFLAMMATORY AGENTS In the context of nociception, mammalian TRPA1 (also known as ANKTM1) was initially suggested to function as a detector of noxious cold and to account for a component of cold sensitivity not mediated by TRPM8 (Story et al. 2003).”
• TRPM8 is required for cold sensation in mice. (2007, positive): “In addition, it is well accepted that cold application is an effective method of pain management ( Sauls, 1999 ).”
• Mechanisms of sensory transduction in the skin (2007, background): “One possible explanation for this behaviour has come from the characterization of TRPA1 (ref”
• TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. (2006, positive): “Most, if not all, TRPA1-positive cells are peptidergic (Bautista et al., 2005; Story et al., 2003), and we therefore asked whether the prevalence of substance P-expressing neurons is affected by the absence of TRPA1.”
• painless, a Drosophila gene essential for nociception. (2003, background): “Thus, we hypothesize that the md-da neurons include pain sensing neurons of the mouse (Story et al., 2003).”
• TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. (2006, positive): “Bradykinin-Induced Pain and Hyperalgesia Subcutaneous bradykinin causes inflammatory pain, and it has been proposed to activate TRPA1 via the B2R G protein-coupled receptor (Story et al., 2003).”
• Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. (2004, methodology): “The extended list ofpressed in a subset of TRPV1-expressing nociceptive neurons (Story et al., 2003).”
• Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors (2005, background): “For example, only 7–25% of rat DRG neurons in culture show a large depolarization or an increase in intracellular free Ca2 concentration in response to cooling to 12–20°C (Suto and Gotoh, 1999; Reid and Flonta, 2001a,b; Babes et al., 2004).”