Autophagy: in sickness and in health.

By A. Cuervo. Trends in Cell Biology, 2004

876 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/c7f4fe20a8bd14812c5f1668656f884d81ea7fbf

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. N. Mizushima
2. D. Klionsky
3. Beth Levine
4. Y. Ohsumi
5. I. Slaninová
6. A. Cuervo
7. T. Yoshimori
8. Yongqiang Chen

In Physiology

1. N. Mizushima
2. D. Klionsky
3. Yongqiang Chen
4. A. Cuervo
5. Y. Ohsumi
6. T. Yoshimori
7. P. Codogno
8. C. Kishi

In Public Health, Environmental and Occupational Health

1. D. Klionsky
2. N. Mizushima
3. C. Glabe
4. V. Weis
5. Y. Ohsumi
6. P. Codogno
7. A. Meijer
8. Yongqiang Chen

Citations in the corpus

• Autophagy and signaling: their role in cell survival and cell death (2005, background): “Readers are referred to recent reviews of the other autophagic pathways.(3,4) Autophagy is an evolutionary mechanism conserved in eukaryotic cells that starts with the formation of an”
• The regulation of autophagy – unanswered questions (2011, background): “The process and mechanism of microautophagy in mammalian cells are still not clear (Cuervo, 2004).”
• New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate (2014, background): “Autophagy is a lysosomal catabolic process that degrades accumulated and unnecessary intracellular materials [17,18,69].”
• Microautophagy: lesser-known self-eating (2011, neutral): “This could be a result of macroautophagy induction under TOR deletion and/or starvation [60, 62].”
• Autophagy: process and function. (2007, background): “Autophagy is a general term for the degradation of cytoplasmic components within lysosomes (Cuervo 2004; Levine and Klionsky 2004; Shintani and Klionsky 2004; Klionsky 2005, 2007; Mizushima and Klionsky 2007).”
• Mechanisms of Cell Death in Oxidative Stress (2007, neutral): “Thus, recent evidence suggests that PKC isoforms may regulate various aspects of the apoptotic program, however the mechanisms and isoform specificity of these interactions are not completely”
• The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. (2008, background): “…role as a starvation response, there is growing evidence for the participation of autophagy in processes such as cellular differentiation, tissue remodeling, growth control, adaptation to adverse environments, and cellular immunity (Cuervo, 2004; Levine and Klionsky, 2004; Yoshimori, 2004).”
• Activation of chaperone-mediated autophagy during oxidative stress. (2004, background): “In mammalian cells three different main mechanisms contribute to the degradation of intracellular components inside lysosomes (autophagy) (Dice, 2000; Reggiori and Klionsky, 2002; Wang and Klionsky, 2003; Cuervo, 2004a,b).”
• The role of autophagy in cancer development and response to therapy (2005, background): “How might this happen? The early stages of tumour development require cancer cells to undergo a higher level of protein synthesis than protein degradation for the tumour to gro”
• Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 (2007, background): “It is activated during amino-acid depriva- tion and has been associated with neurodegenerative dis- eases, cancer, pathogen infections and myopathies (reviewed in Cuervo, 2004; Shintani and Klionsky, 2004).”
• The role of autophagy during the early neonatal starvation period (2004, background): “Autophagy is the primary means for the degradation of cytoplasmic constituents within lysosome”
• Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. (2008, background): “Macroautophagy, hereafter referred to simply as autophagy, is a bulk degradation process occurring in cells and is conserved in all eukaryotes (Cuervo, 2004; Levine and Klionsky, 2004; Klionsky, 2007; Mizushima, 2007; Mizushima et al., 2008).”