The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy.

1,108 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages (2009, methodology): “Gel filtration analysis was performed as described previousl”
Autophagy during viral infection — a double-edged sword (2018, background): “Autophagy is controlled by the sequential activities of three key protein complexes: the serine/threonine protein kinase ulK1 complex (comprising ulK1, FAK family kinase-interacting protein of 200 kDa (FIP200; also known as RB1CC1), ATG13 and ATG101) [146] [147] [148] ; the phosphoinositide 3-kinase”
Autophagy, Immunity, and Microbial Adaptations (2009, background): “…conjugate that associates noncovalently with Atg16L1 (the mammalian equivalent of yeast Atg16) to form a putative E3 enzyme (terminology borrowed from the ubiquitin system) (Hanada et al., 2007), directing the site of the formation of the second protein-lipid conjugate (Fujita et al., 2008).”
An Overview of Autophagy: Morphology, Mechanism, and Regulation (2014, background): “The Atg12–Atg5 conjugate, which may act as an E3 ligase, facilitates this final step (30, 37, 52).”