Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.

By Eisuke Itakura, C. Kishi, Kinji Inoue, N. Mizushima. Molecular Biology of the Cell, 2008

1,189 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/6da527ed4bf7bec7dc2a7e1598a1450218795be2

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Citations in the corpus

Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy (2013, background): “The Atg14L and UVRAG-IPs contained Vps34, p150, Beclin1, and Atg14L or UVRAG in amutually exclusivemanner, as previously reported (Itakura et al., 2008).”
Endosome maturation (2011, background): “Together, these form a core complex (Funderburk et al, 2010), which on endosomes associates with a protein called UVRAG (Itakura et al, 2008), an activator of the HOPS complex.”
Principles and Current Strategies for Targeting Autophagy for Cancer Treatment (2011, background): “For example, PI3K/ Beclin1 complexed with UVRAG and Bif-1 (21) can activate autophagy onmembranes, whereas PI3K/Beclin1 complexed to Rubicon (22) plays an inhibitory role in membrane trafficking of AV to lysosomes.”
Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “One of these proteins is UVRAG (functionally related to Vps38) (709), which promotes autophagy either by recruiting curvature-sensing BAR-domain containing proteins (317, 1517) or by enhancing fusion of autophagosomes with lysosomes (908).”
The Roles of Autophagy in Cancer (2018, background): “Spautin-1 inhibits autophagy and leads to the induction of proteasomal removal of class III PI3K kinase complexes [177].”
Autophagy, Immunity, and Microbial Adaptations (2009, background): “, 2009), and (2) UVRAG/VPS38, which plays a role in maturation (Itakura et al., 2008; Liang et al., 2008) and is negatively regulated by Rubicon (Matsunaga et al.”
Regulation Mechanisms and Signaling Pathways of Autophagy (2009, background): “The nucleation and assembly of the initial phagophore membrane requires the class III phosphatidylinositol 3-kinase (PtdIns3K) complex, which is composed of the PtdIns3K Vps34 (vacuolar protein sorting 34), a myristoylated serine/threonine kinase Vps15 (p150 in mammalian cells), Atg14 (Barkor or mAt”
Deciphering the Molecular Signals of PINK1/Parkin Mitophagy. (2016, background): “Atg14 is a component of the class III phosphatidylinositol 3kinase complex, where it functions in forming the isolation membrane [70].”
Molecular definitions of autophagy and related processes (2017, neutral): “…subunit 4 (PI3KR4; best known as VPS15) (Kihara et al , 2001a, b), the sensor of membrane curvature ATG14 (also known as ATG14L or BARKOR) (Itakura et al , 2008; Sun et al , 2008; Matsunaga et al , 2009; Zhong et al , 2009; Fan et al , 2011), and nuclear receptor binding factor 2 (NRBF2)…”
Molecular characterization of LC3-associated phagocytosis (LAP) reveals distinct roles for Rubicon, NOX2, and autophagy proteins (2015, neutral): “ATG14 and UVRAG are mutually exclusive in their association with the Class III PI(3)K complex during autophagy 26 , and silencing of either ATG14 (refs 15,26) or UVRAG (ref.”
ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase (2013, methodology): “Active GST-ULK1 (1-649) and GST-ULK2 (1-478) from insect cells was purchased from CQuential Solutions (Moraga, CA).”