Activation of chaperone-mediated autophagy during oxidative stress.

By R. Kiffin, Christopher Christian, E. Knecht, A. Cuervo. Molecular Biology of the Cell, 2004

626 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c33e735fe173585899b1ad93c223f9a0f40f3b8a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Yongqiang Chen
2. D. Klionsky
3. A. Cuervo
4. Katherine R Parzych
5. R. Kiffin
6. Urmi Bandyopadhyay
7. Christopher A. Ross
8. Craig B. Thompson

In Epidemiology

1. Yongqiang Chen
2. D. Klionsky
3. Katherine R Parzych
4. A. Cuervo
5. S. Gibson
6. M. Azad
7. N. Mizushima
8. Craig B. Thompson

In Molecular Biology

1. A. Cuervo
2. Yongqiang Chen
3. Katherine R Parzych
4. Craig B. Thompson
5. J. Lum
6. S. Gibson
7. M. Azad
8. Christopher A. Ross

Citations in the corpus

• Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment (2009, positive): “Whereas antioxidant enzymes such as SOD and catalase (which actively scavenge ROS) can be considered the first line of defense against oxidative damage, autophagy provides a second line of defense by removing oxidatively damaged proteins and impaired organelles (12, 53).”
• What is the role of protein aggregation in neurodegeneration? (2005, background): “Chaperone-mediated autophagy can be activated by oxidative stres”
• An Overview of Autophagy: Morphology, Mechanism, and Regulation (2014, background): “Mild oxidative stress (66), protein-damaging toxins (21), and extended periods of nutrient deprivation all upregulate CMA (6, 22), but the intracellular signaling pathways that facilitate this change are not fully understood (3).”
• Oxidative Stress and Autophagy (2006, positive): “Of special interest is the current utilization of yeast for the study of the effect of lipid oxidation in the activity of the different proteolytic systems, and in particular of autophagy (47). experimental model”
• Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. (2007, background): “Autophagy, by targeting cytoplasmic proteins and organelles for lysosomal degradation, plays a role in recycling organelles and proteins that may be damaged by increased reactive oxygen species generated by the cellular stress associated with activated oncogenes and cancer therapies (7, 8).”