Autophagy and signaling: their role in cell survival and cell death

By P. Codogno, A. Meijer. Cell Death and Differentiation, 2005

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Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells (2008, background): “Autophagic cell death remains controversial since autophagy contributes to cell survival under stress such as starvation.(4) In mice lacking autophagy, neural cell death is increased leading to neurological disorders.”
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. (2009, background): “Among the many factors that have thus far been reported (Codogno and Meijer, 2005; Meijer and Codogno, 2006; Mizushima, 2007), (mammalian) target of rapamycin [(m)TOR]-mediated suppression appears to be a highly conserved, major regulatory mechanism.”
Mechanisms of diabetic complications. (2013, background): “Insulin is a known inhibitor of autophagy where it acts to limit the formation of autophagosomes (110, 365).”
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 (2007, background): “A growing body of evidence suggests that autophagy plays a dual role, both in survival and in death-related pathways (Cuervo, 2003; Codogno and Meijer, 2005; Reef et al, 2006).”