Autophagy: process and function.

By N. Mizushima. Genes & Development, 2007

3,963 citations recorded by the source corpus.

Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are sometimes complex. Autophagy consists of several sequential steps--sequestration, transport to lysosomes, degradation, and utilization of degradation products--and each step may exert different function. In this review, the process of autophagy is summarized, and the role of autophagy is discussed in a process-based manner.

Subfields: Epidemiology, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/602050b4a5d8f8f83172b7d392e13a5cb3fe10ac

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Citations in the corpus

Hallmarks of cancer: the next generation. (2011, positive): “Autophagy represents an important cell-physiologic response that, like apoptosis, normally operates at low, basal levels in cells but can be strongly induced in certain states of cellular stress, the most obvious of which is nutrient deﬁciency (Levine and Kroemer, 2008; Mizushima, 2007).”
Autophagy: cellular and molecular mechanisms (2010, background): “There are two ubiquitin-like systems that are key to autophagy [5,34] acting at the Atg5–Atg12 conjugation step and at the LC3 processing step (see below).”
Autophagy in malignant transformation and cancer progression (2015, positive): “As an increasing number of activities is being ascribed to these and other autophagy mediators (Cosse et al , 2010; Lee et al , 2012; Liu et al , 2012a; Moscat & Diaz-Meco, 2012; Zhao et al , 2012; Maskey et al , 2013; Elgendy et al , 2014), it remains possible that other, autophagy-independent func”
Role of autophagy in cancer (2007, background): “jpg" NDATA ITEM> ]> Autophagy is a cellular catabolic degradation response to starvation or stress whereby cellular proteins, organelles and cytoplasm are engulfed, digested and recycled to sustain cellular metabolis”
Autophagy as a target for anticancer therapy (2011, background): “Microautophagy refers to direct delivery of cytosolic components by invagination through the lysosomal membrane, whereas chaperone-mediated autophagy is a selective mechanism for degradation of soluble cytosolic proteins in lysosomes”
FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport (2010, background): “This way, the cytosolic cargo is delivered for degradation by lysosomal proteases (Mizushima, 2007; Xie and Klionsky, 2007).”
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies (2023, background): “is an essential process that maintains cellular homeostasis via the lysosome-dependent degradation of cellular components, such as proteins and organelles, allowing cells to recycle macromolecules 258,259 .”
p62 links autophagy and Nrf2 signaling. (2015, background): “Thus, similar to Nrf2, autophagy plays seemingly contradictory roles in cancer [9,16,17], and the roles of Nrf2 and autophagy in cancer are context-dependent.”
Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation (2010, background): “Bulk or nonselective autophagy is a constitutively active and evolutionarily conserved process that is upregulated in response to a diverse range of cellular stresses.(1) The process is characterized by the formation of a double-membrane vesicle that can engulf intracellular organelles and cytosolic”
Mitophagy: mechanisms, pathophysiological roles, and analysis (2012, background): “…is a genetically programmed, evolutionarily conserved catabolic process that degrades cellular proteins, and damaged or excessive organelles through the formation of a double-membrane structure known as the autophagosome (Mizushima , 2007 ; Nakatogawa et al. , 2009 ; Yang and Klionsky , 2010 ).”
Dengue virus induced autophagy regulates lipid metabolism (2010, background): “Autophagy is a cellular process by which cytoplasmic components are sequestered in double-membrane vesicles and degraded to maintain cellular homeostasis (Mizushima, 2007).”
Autophagy and autophagy-related proteins in cancer (2020, background): “mitochondria) and eliminate proteins aggregates [32], and inhibitors of TOR such as rapamycin and CCI-779 [17].”
Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets (2019, background): “Macroautophagy is amongst the best-characterized autophagy subtype, which is a multi-step process that involves sequestration of cytoplasmic components such as damaged organelles and proteins in doublemembrane structures known as autophagosomes, followed by fusion with lysosomes whereby proteolytic ”