Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

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Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease (2010, background): “Although ROS have been implicated in the regulation of starvation-induced autophagy (17), their general significance in mediation of autophagy has not been appreciated.”
Toll‐like receptors control autophagy (2008, neutral): “Toll-like receptors control autophagy”
Cell Death Pathways in Photodynamic Therapy of Cancer (2011, background): “In general, mammalian cells use autophagy as a defense against ROS mediated damage by clearing the cell of damaged organelles [117].”
Mitochondria and Mitophagy: The Yin and Yang of Cell Death Control (2012, background): “ATG4 is subject to oxidation and subsequent inactivation, which leads to accumulation of LC3-II and increased formation of autophagosomes.(159) Interestingly, increased oxidative/nitrosative stress can inhibit mitophagy by modification and inactivation of Parkin.”
Pancreatic cancers require autophagy for tumor growth. (2011, positive): “Autophagy inhibition in PDAC results in increased reactive oxygen species (ROS), DNA damage, and altered cell metabolism Autophagy has been shown to be regulated by ROS (Chen et al. 2007; Scherz-Shouval et al. 2007; Dewaele et al. 2010).”
Broad targeting of resistance to apoptosis in cancer (2015, background): “[70] Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z.”