Stem Cells and Their Niches

By K. Moore, Ihor R. Lemischka. Science, 2006

1,636 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/c779ad5f2575f505c9368955c6c6fb8b0810aca8

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Citations in the corpus

Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche (2007, background): “The bulge of the hair follicle, crypt and perivascular region provide niche microenvironments for epidermal, intestinal and neural stem cells, respectively, perhaps through multiple signaling pathway”
Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity (2008, background): “When regarding normal stem cells as the paradigm, it seems logical to assume that this is regulated by a niche that provides coordinated signals (21, 22).”
Epithelial stem cells: turning over new leaves. (2007, neutral): “(Moore and Lemischka, 2006).”
Making a tumour's bed: glioblastoma stem cells and the vascular niche (2007, background): “However, it has long been recognized that normal stem cells of various tissues are tightly regulated by the immediate microenvironment or stem cell nich”
Long-term propagation of distinct hematopoietic differentiation programs in vivo. (2007, background): “Nevertheless, the extent to which this heterogeneity may reflect a predetermined intrinsic diversity (MullerSieburg and Sieburg, 2006), or chance exposure to different environments (Trentin, 1971; Metcalf, 1998; Moore and Lemischka, 2006), or stochastic events affecting intrinsic pathways (Till et a”
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow (2009, background): “The cells showed expression of Ang-1 in the PS cells and of CXCL12 in the PDGFR+Sca-1 cells, suggesting that the MSCs constitute a hematopoietic niche in the arterial perivascular area near the endosteum (Moore and Lemischka, 2006).”
Extracellular matrix dynamics in development and regenerative medicine (2008, background): “Supporting niche cells, the ECM and growth-modulating factors stored within it, and the physical characteristics of the surrounding 3D structures, all contribute to the niche (Haylock and Nilsson, 2005; Moore and Lemischka, 2006).”
A perivascular niche for brain tumor stem cells. (2007, background): “Stem cells of various tissues exist within protective niches that are composed of a number of differentiated cell types (Fuchs et al., 2004; Moore and Lemischka, 2006).”
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery (2009, background): “The behaviour of normal stem cells is tightly regulated by signals that the cells receive from their microenvironmental niches, which are provided by the adjacent cells and/or extracellular matrix component”
Melanocyte biology and skin pigmentation (2007, background): “Multipotent epidermal stem cells exist in the bulge region (at the bottom of the permanent portion of the follicle, just below the sebaceous gland”