A perivascular niche for brain tumor stem cells.

By C. Calabrese, H. Poppleton, M. Koçak, T. Hogg, C. Fuller, Blair Hamner, Eun Young Oh, M. Gaber, David Finklestein, Meredith Allen and 6 more. Cancer Cell, 2007

2,227 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/ea99006ea76bcd028b68581a40926d6cc1b30a9f

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Citations in the corpus

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment (2010, background): “Previous observations by us and others have suggested that brain CSCs are also supported by (perivascular) endothelial cell”
The brain tumor microenvironment (2011, background): “These angiogenic regions of which, the perivascular niche is a part, have emerged as important locations responsible for the maintenance of brain tumor stem cell-like (BTSC) populations (Calabrese et al., 2007; Charles et al., 2010; Hambardzumyan et al., 2008).”
Cancer stem cells in glioblastoma (2015, background): “CSCs located at the perivascular niche are in close contact with the endothelial cells (Calabrese et al. 2007), permitting engagement of endothelial cell Notch ligands with glioma CSC Notch receptors to activate Notch signaling, which supports self-renewal of glioma CSCs (Zhu et al.”
Targeting cancer stem cell pathways for cancer therapy (2020, background): “417 demonstrated that direct contact between ECs and CSCs occurs in brain tumors.”
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “…suggests that these cells tend to reside closer to blood Cell 132, 598–611, February 22, 2008 ª2008 Elsevier Inc. 607 vessels than other brain tumor cells and that vascular cells promote the maintenance of brain tumor stem cells in culture and promote tumorigenesis in vivo (Calabrese et al., 2007).”
CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells (2008, background): “Interestingly, a recent study showed that CD133 positive glioma cells were maintained within vascular niches and could be ablated following anti-angiogenic treatment.(45) The capacity for angiogenesis-independent growth displayed by brain tumors would then imply that the CD133 positive tumorgenic ce”
Real-time imaging reveals the single steps of brain metastasis formation (2010, background): “Another essential step was the perpetuation of a strict perivascular position, which probably provides an optimal oxygen supply and access to nutrient”
The microenvironmental landscape of brain tumors (2017, background): “nitric oxide) that maintain the tumor-initiating cell pool (Calabrese et al., 2007; Charles and Holland, 2010; Charles et al., 2010; Gilbertson and Rich, 2007; Hambardzumyan et al., 2008; Lathia et al., 2010; Lathia et al., 2015; Pietras et al., 2014), and similar results have been shown in the NSC-”
Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma (2010, background): “It has recently been shown that CSCs from various brain tumours, including glioblastoma and medulloblastoma, exist in a perivascular niche that is analogous to that of their non-neoplastic counterpart”
Making a tumour's bed: glioblastoma stem cells and the vascular niche (2007, background): “However, a series of recently published studies have shown that aberrant vascular stem cell niches, reminiscent of those observed in the normal brain, exist in glioblastoma and other types of brain tumour and support the cancer stem cell”