Long-term propagation of distinct hematopoietic differentiation programs in vivo.

By B. Dykstra, D. Kent, Michelle B. Bowie, Lindsay McCaffrey, M. Hamilton, Kristin Lyons, Shang-Jung Lee, Ryan Remy Brinkman, C. Eaves. Cell Stem Cell, 2007

652 citations recorded by the source corpus.

Subfields: Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/273425759b7db11c5cb0fdd6edb85a248715bd15

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In Hematology

1. S. Morrison
2. Irving L. Weissman
3. Derrick J. Rossi
4. Benjamin L. Ebert
5. A. Wagers
6. David Bryder
7. Margaret A. Goodell
8. Lei Ding

In Immunology

1. S. Morrison
2. Derrick J. Rossi
3. Aviv Regev
4. Irving L. Weissman
5. Fabian J Theis
6. A. Wagers

Citations in the corpus

• Diffusion maps for high-dimensional single-cell analysis of differentiation data (2015, background): “Moreover, stem cell populations that have been functionally characterised often show heterogeneity in their cellular and molecular properties (Huang, 2009; Dykstra et al., 2007; Stingl et al., 2006).”
• SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors (2013, background): “HSCs are also heterogeneous with respect to the ratio of myeloid to lymphoid cells that they generate upon transplantation into irradiated mice (Müller-Sieburg et al., 2002; Dykstra et al., 2007; Kent et al., 2009; Beerman et al., 2010; Challen et al., 2010; Morita et al., 2010) and with respect to ”
• Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. (2013, neutral): “Subsets of HSCs (myeloid-biased, balanced, and lymphoid-biased HSCs; and a, b, g, and d cells) are reported by other groups (Mü ller-Sieburg et al., 2002; Dykstra et al., 2007).”
• Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGFβ1 (2010, positive): “demonstrated that HSC activity could be classified by four behaviors according to their lineage differentiation capacity as well as the length of time over which they could contribute to high levels of blood production (Dykstra et al., 2007).”
• Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion (2010, background): “Indeed, an important study using extensive single-cell transplantation of highly purified stem cells demonstrated that the clonal contribution to the different blood cell lineages varies significantly and can be stably maintained through serial passaging, providing evidence that the pool of HSCs com”
• Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. (2009, neutral): “Very Low Cycling Activity of CD34LSKCD150CD48 Cells As ‘‘proof of principle’’ that mouse HSCs are bona fide adult stem cells, several investigators have succeeded in performing single-cell repopulation assays using BM subsets isolated by flow cytometry (Camargo et al., 2006; Dykstra et al., 2007; Wa”
• Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells (2015, methodology): “2010) and in the ratio of myeloid to lymphoid cells that they generate upon transplantation into irradiated mice (Muller-Sieburg et al. 2002; Dykstra et al. 2007; Kent et al. 2009; Beerman et al. 2010; Challen et al. 2010; Morita et al. 2010).”
• Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions (2015, neutral): “…transplantation experiments have further demonstrated that even HSCs with identical surface phenotypes are heterogeneous in their engraftment behaviors, with different stabilities over time and variable degrees of myeloid versus lymphoid lineage output (Dykstra et al., 2007; Yamamoto et al., 2013).”