Making a tumour's bed: glioblastoma stem cells and the vascular niche

By Richard J. Gilbertson, Jeremy N. Rich. Nature Reviews. Cancer, 2007

748 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Oncology

View Paper: https://www.semanticscholar.org/paper/eab6578b761116fe7abd2be160bf7f8af8a16a7a

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Citations in the corpus

The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, neutral): “Hedgehog and NOTCH signaling pathways (Gilbertson and Rich, 2007) require cell-cell contact.”
Hallmarks of cancer: the next generation. (2011, neutral): “, 2001; Bonnet and Dick, 1997) and then years later were identified in solid tumors, in particular breast carcinomas and neuroectodermal tumors (Gilbertson and Rich, 2007; Al-Hajj et al., 2003).”
Cancer stem cells: current status and evolving complexities. (2012, background): “CSCs in fresh glioblastoma specimens or glioma xenografts are more resistant to ionizing irradiation (IR) in vivo than non-CSCs because of enhanced DNA repair pathways operating in CSCs (reviewed in Gilbertson and Rich, 2007).”
Integrin alpha 6 regulates glioblastoma stem cells (2010, background): “Extracellular matrix (ECM) proteins are key structural components of the perivascular niche and regulate normal stem cell and tumor proliferation and migration (Gilbertson and Rich, 2007).”
Exploring the role of cancer stem cells in radioresistance (2008, background): “, are established in niches composed of heterologous cell types, matrix and signal proteins that contribute to regulation and maintenance of the cancer stem cell poo”
Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh (2009, background): “The niche includes astrocytes, ependyma and non-neural cell types, such as endothelial cell”
Adult SVZ stem cells lie in a vascular niche: A quantitative analysis of niche cell-cell interactions (2008, neutral): “Moreover, brain cancer stem cells have an affinity for blood vessels , migrating along them during tumor spread and stimulating their growth through VEGF secretion (Gilbertson and Rich, 2007).”
The microenvironmental landscape of brain tumors (2017, result): “…factors (e.g., nitric oxide) that maintain the tumor-initiating cell pool (Calabrese et al., 2007; Charles and Holland, 2010; Charles et al., 2010; Gilbertson and Rich, 2007; Hambardzumyan et al., 2008; Lathia et al., 2010, 2015; Pietras et al., 2014), and similar results have been shown in the…”
Targeting cancer stem cell pathways for cancer therapy (2020, neutral): “437, 438 The hypoxia microenvironment and CSCs.”
The blood-brain barrier in brain homeostasis and neurological diseases. (2009, neutral): “In addition, it was recently emphasized that brain ECs may closely interact with brain tumor stem cells such as gliobastoma stem cells [143] and maintain their stemness [144].”
Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells (2009, background): “We previously demonstrated that the VEGF neutralizing antibody bevacizumab (Avastin) specifically inhibits the proangiogenic effects of GSCs (Bao et al., 2006b), suggesting that anti-VEGF therapies might disrupt the stem cell niche (Calabrese et al., 2007; Gilbertson and Rich, 2007).”
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia (2012, background): “In fact, emerging evidence has implicated a number of vascular-derived factors that can regulate CSCs (36, 37).”