TOR signalling in bugs, brain and brawn

By E. Jacinto, Michael N. Hall. Nature reviews. Molecular cell biology, 2003

595 citations recorded by the source corpus.

Subfields: Ecology, Evolution, Behavior and Systematics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c4a2442d5f8f846cfbebca1bebf949c95175e947

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology, Evolution, Behavior and Systematics

1. Nahum Sonenberg
2. J. Blenis
3. N. Hay
4. D. Klionsky
5. E. Jacinto
6. R. Loewith
7. K. Guan
8. K. Inoki

In Molecular Biology

1. David M. Sabatini
2. Michael N. Hall
3. K. Guan
4. Nahum Sonenberg
5. D. Klionsky
6. N. Hay
7. J. Blenis
8. S. Yamanaka

Citations in the corpus

• Rheb binds and regulates the mTOR kinase. (2005, unknown): “cerevisiae as well as in metazoans [1, 2].”
• Dysregulation of the TSC-mTOR pathway in human disease (2004, background): “TOR regulates a wide array of cellular functions, including translation, transcription, mRNA turnover, protein stability, actin cytoskeletal organization and autophag”
• The tor pathway: a target for cancer therapy (2004, background): “It is highly conserved from yeast to mammals — human, mouse and rat TOR proteins share 95% identity at the amino-acid leve”
• Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive (2004, background): “Thus it functions as a temporal regulator of cell growt”
• mTOR, translation initiation and cancer (2006, background): “…et al., 2005; Stephens et al., 2005; Petroulakis et al., 2006) (Figure 2). mTOR promotes the phosphorylation and activation of S6K and the hierarchial phosphorylation the 4E-BPs (Gingras et al., 2001; Jacinto and Hall, 2003; Kim et al., 2003; Ruggero and Pandolfi, 2003; Kim and Sabatini, 2004).”
• SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. (2006, background): “An important player in the control of cell growth is the evolutionarily conserved protein kinase, target of rapamycin (TOR) (Jacinto and Hall, 2003; Sarbassov et al., 2005a; Wullschleger et al., 2006).”
• Upstream and downstream of mTOR. (2004, background): “4, the mammalian homolog of TAP42, is also involved in the dephosphorylation of 4E-BP1 and S6K (for review, see Jacinto and Hall 2003). eIF4G eIF4G is a modular scaffolding protein that plays a key role in the assembly of the ribosome initiation complex.”
• Microautophagy: lesser-known self-eating (2011, unknown): “In a Tap42-dependent mechanism, TOR depletion or rapamycin treatment leads to the destabilization of eIF4G, inhibition of ribosome biogenesis, and activation of Gcn2 [39, 43].”
• Role and regulation of starvation-induced autophagy in the Drosophila fat body. (2004, background): “These proteins sense nutritional status by an unknown mechanism, and effect a variety of starvation responses including changes in transcriptional and translational programs, nutrient import, protein and mRNA stability, cell cycle arrest, and induction of autophagy (Jacinto and Hall, 2003).”
• mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells (2004, background): “Mammalian TOR (mTOR; also known as FRAP [FKBP12rapamycin-associated protein], RAFT [rapamycin and FKBP12 target], and RAPT [rapamycin target]) belongs to the phosphoinositide kinase-related kinase (PIKK) family (21, 48).”
• Molecular mechanisms of mTOR-mediated translational control (2009, background): “Mammalian TOR complex 1 (mTORC1), which contains mTOR (also known as FRAP1) in complex with raptor (regulatory associated protein of mTOR) and LST8 (also known as GβL), directly regulates protein synthesis in mammal”