Role and regulation of starvation-induced autophagy in the Drosophila fat body.

By R. C. Scott, Oren Schuldiner, T. P. Neufeld. Developmental Cell, 2004

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View Paper: https://www.semanticscholar.org/paper/1326da7cac604e2af2330b875cbc6fefe21eff08

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Citations in the corpus

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster (2010, background): “Ubiquitous double-stranded RNA interference against Atg5, which inhibits autophagy induction (Ren et al., 2009; Scott et al., 2004), resulted in an approximate 2-fold reduction in Atg5 expression as determined by QPCR (Figure S3) and completely abrogated the extension of life span by rapamycin…”
TOR signaling in growth and metabolism. (2006, background): “Recent studies have highlighted the existence of a negative feedback loop from the nutrient-sensitive TSC-mTOR-S6K1 pathway to the upstream, insulin-responsive IRS-PI3K-PDK1Akt pathway (Figure 2; Harrington et al., 2004; Shah et al., 2004; Um et al., 2004).”
Guidelines for the use and interpretation of assays for monitoring autophagy (2012, methodology): “23).(197,198) However, additional assays, such as GFP-Atg8/LC3 fluorescence or EM, should be used to substantiate results obtained with acidotropic dyes whenever possible.”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “Among the older methods for following autophagy is staining with acidotropic dyes such as monodansylcadaverine,(1129) acridine orange,(1130) Neutral Red,(956) LysoSensor Blue(1131) and LysoTracker Red.(280,1132) It should be emphasized that, whereas these dyes are useful to identify acidified vesicu”
Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. (2007, positive): “Lysotracker is an acidophilic dye that has been used to detect autophagy ( Scott et al., 2004 ), and we used it as an alternative to GFP-LC3 because of a GFP reporter that is associated with the Atg1 transgene.”
An Overview of the Molecular Mechanism of Autophagy (2009, background): “Homologs of Atg1 are involved in autophagy in various multicellular organisms such as Dictyostelium discoideum (Otto et al. 2004), Drosophila melanogaster (Scott et al. 2004), C. elegans (Melendez et al. 2003), Arabidopsis thaliana (Hanaoka et al. 2002), and mammals (Yan et al. 1998, 1999).”
A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans (2008, background): “In this organism, autophagy is controlled by the ATG genes, many of which have functional homologs in other organisms [13,15].”
Regulation of TORC1 by Rag GTPases in nutrient response (2008, neutral): “Autophagy can be readily imaged in vivo using markers such as GFP–Atg8 and Lysotracke”
Growth factor regulation of autophagy and cell survival in the absence of apoptosis. (2005, methodology): “Following growth factor Melendez et al., 2003; Scott et al., 2004; Kuma et al.,withdrawal, Bax / Bak / cells activate autophagy, un2004).”
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. (2009, background): “TOR is a serine/threonine protein kinase whose activity is inhibited by nutrient starvation, and its inhibition induces autophagy (Noda and Ohsumi, 1998; Schmelzle and Hall, 2000; Scott et al., 2004).”