Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.

By Hua Cai, David G. Harrison. Circulation Research, 2000

3,015 citations recorded by the source corpus.

Subfields: Biochemistry, Cardiology and Cardiovascular Medicine, Physiology

View Paper: https://www.semanticscholar.org/paper/c3f64c6510e09a1fb10553765445b8a5941c383b

Citations in the corpus

• Potential Adverse Effects of Resveratrol: A Literature Review (2020, neutral): “In this context, a higher dose of RE (1000mg/day) was recently shown to elevate biomarkers of CVD risk (oxidized low-density lipoprotein (ox-LDL), soluble E-selectin 1 (sE-selectin 1), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and total”
• A review of the interaction among dietary antioxidants and reactive oxygen species. (2007, neutral): “Oxidized lipids can affect cell function by accumulating in the cell membrane, causing leakage of the plasmolemma and interfering with the function of membrane-bound receptors [85].”
• The discovery of nitric oxide and its role in vascular biology (2006, neutral): “The uncoupling of eNOS has been reported to occur in several pathological conditions such as diabetes, hypercholesterolaemia and hypertension (Cai & Harrison, 2000; Moncada, 2005).”
• Angiotensin-converting enzyme 2 is an essential regulator of heart function (2002, neutral): “It has been established that AngII can induce oxidative stress in endothelial cell”
• The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy (2017, neutral): “E2 failed to increase homing of EPCs to the injured myocardium in eNOS-null mice [68].”
• Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. (2003, neutral): “An attractive explanation for this association relates to vascular oxidant stress (1, 2).”
• Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword? (2007, neutral): “…environmental pollutants, and also as byproducts of oxygen(using enzymatic reactions, such as the mitochondrial respiratory chain, the arachidonic acid pathway, the cytochrome P450 family, glucose oxidase, amino acid oxidases, xanthine oxidase, NADPH/NADPH oxidases, or NO synthases (11, 31) (Fig.”
• Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities (2011, neutral): “Importantly, endothelial dysfunction is considered a marker for increased cardiovascular risk (51, 84).”
• Endothelial dysfunction - a major mediator of diabetic vascular disease. (2013, neutral): “14 consequences of oxidative stress in human subjects is impaired endothelium-dependent vasodilation [109].”
• NADPH Oxidases in Cardiovascular Health and Disease (2006, neutral): “salt) appears to be endothelin-1 (210, 379).”
• Endothelial Dysfunction and Diabetes: Effects on Angiogenesis, Vascular Remodeling, and Wound Healing (2012, neutral): “Endothelial dysfunction can result from and/or contribute to several disease processes, as occurs in diabetes mellitus, hypercholesterolemia and hypertension, and also due to environmental factors, such as smoking tobacco products and exposure to air pollution [9].”
• The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature (2017, neutral): “Effects of CGA on endothelial function It is well-known that the impairment of endothelial function, which develops in diseases, such as hypertension, diabetes [35], metabolic syndrome [35, 36] and others,”
• New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy. (2003, neutral): “It has been suggested that, in diabetes, oxidative stress plays a key role in the pathogenesis of vascular complications, both microvascular and macrovascular (6), and an early marker of such damage is the development of an endothelial dysfunction (6,7).”
• Prognostic Value of Coronary Vascular Endothelial Dysfunction (2002, neutral): “29.70.4 30.20.6 29.60.5 LV dysfunction 25 (8) 11 (6) 14 ( 10 )”
• The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors (2002, neutral): “In addition, recent studies have established that oxygen- and nitrogen-derived oxidants and free radicals play a significant role in diabetes-associated endothelial dysfunction (Giugliano et al., 1996; Honing et al., 1998; Lyall et al., 1998; Cai and Harrison, 2000).”
• Oxidation events and skin aging. (2015, neutral): “Membrane lipid damage further leads to altered membrane fluidity, cell membrane leakage or dysfunction of membrane-bound cellular receptors (Cai and Harrison, 2000).”