Endothelial Dysfunction and Diabetes: Effects on Angiogenesis, Vascular Remodeling, and Wound Healing

By G. Kolluru, S. Bir, C. Kevil. International Journal of Vascular Medicine, 2012

696 citations recorded by the source corpus.

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate hyperglycemia due to lack of or resistance to insulin. Patients with DM are frequently afflicted with ischemic vascular disease or wound healing defect. It is well known that type 2 DM causes amplification of the atherosclerotic process, endothelial cell dysfunction, glycosylation of extracellular matrix proteins, and vascular denervation. These complications ultimately lead to impairment of neovascularization and diabetic wound healing. Therapeutic angiogenesis remains an attractive treatment modality for chronic ischemic disorders including PAD and/or diabetic wound healing. Many experimental studies have identified better approaches for diabetic cardiovascular complications, however, successful clinical translation has been limited possibly due to the narrow therapeutic targets of these agents or the lack of rigorous evaluation of pathology and therapeutic mechanisms in experimental models of disease. This paper discusses the current body of evidence identifying endothelial dysfunction and impaired angiogenesis during diabetes.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/0a65e28f54c8671a7423fe70e889eb0d5071cd33

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In Molecular Biology

1. Uzoagu A Okonkwo
2. L. DiPietro

Citations in the corpus

• Diabetes and Wound Angiogenesis (2017, background): “This deficit in turn, reduces the baseline vascularity in diabetic tissues and likely affects wound angiogenesis [99].”