Angiotensin-converting enzyme 2 is an essential regulator of heart function

By M. Crackower, R. Sarao, G. Oudit, C. Yagil, I. Kozieradzki, S. Scanga, A. Oliveira-dos-Santos, Joan da Costa, Liyong Zhang, Y. Pei and 7 more. Nature, 2002

1,732 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Ecology, Physiology

View Paper: https://www.semanticscholar.org/paper/24138e755fac74aa541a5c78097d159b1b0f5f27

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In Cardiology and Cardiovascular Medicine

In Physiology

Citations in the corpus

Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis (2004, background): “The physiological role of ACE2 in most tissues has not been elucidated, although ACE2 is thought to be an essential regulator of cardiac function and blood pressure control [9], possibly by acting as a natural counterpart of ACE1 [14].”
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. (2007, background): “A recently identified carboxypeptidase, ACE2, cleaves one amino acid from either ANG I or ANG II (29), decreasing ANG II levels and increasing the metabolite Ang 1–7, which has vasodilator properties.”
Biomarkers associated with COVID-19 disease progression (2020, background): “Ang II levels were found to be significantly increased in the kidneys, hearts, and plasma of ACE2 null mice [95].”
Role of the ACE2/Angiotensin 1–7 axis of the Renin-Angiotensin System in Heart Failure (2016, background): “ACE2 knockout mice also showed increased Ang II levels, which were rescued with genetic ablation of ACE.(7) Consistently, we found age-dependent dilated cardiomyopathy in ACE2 knockout mice.”
Renin‐angiotensin system revisited (2008, background): “Disruption of the ACE2 gene in mice was reported to result in a severe cardiac contractility defect, increased Ang II plasma levels and upregulation of cardiac hypoxia-induced genes [42] .”
COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up (2020, background): “DIC is common in many patients with critical illness (113), including those with COVID-19 (7,114).”
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2 (2020, positive): “Given the fact that cardiac cells express high levels of ACE2, and heart alterations were the first phenotype observed in our ace2mutant mice (Crackower et al., 2002), it will be important to expand on our studies to heart and in particular lung organoids to better understand the multi-organ dysfunc”
Physiology of local renin-angiotensin systems. (2006, background): “Crackower et al. (119) performed a number of knock-out studies in mice and Drosophila, and while there were only modest effects on blood pressure in mice, the genetic manipulation resulted in severe changes in cardiac contractility, combined with increases of cardiac ANG II levels and the induction ”