New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy.

By Antonio Ceriello. Diabetes Care, 2003

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Postprandial hyperglycemia and diabetes complications: is it time to treat? (2005, background): “These processes result in acute endothelial dysfunction in diabetic blood vessels that, convincingly, contributes to the development of CVD (59).”
Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. (2006, background): “…accepted as playing a key mediatory role in the development and progression of diabetes and its complications due to increased production of free radicals and impaired antioxidant defenses (Ha and Lee, 2000; Bonnefont-Rousselot, 2002; Evans et al., 2003; Ceriello, 2003; Maritim et al., 2003).”
Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010, neutral): “…it should be recognized that considerable ROS derives from outside this organelle, including oxygen radicals from peroxisomal b -oxidation of fatty acids (24), NAD(P)H oxidase (53), xanthine oxidase, arachidonic acid metabolism, microsomal P-450 enzymes (75), and the prooxidant heme molecule (226).”