Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword?

By J. Malhotra, R. Kaufman. Antioxidants and Redox Signaling, 2007

1,486 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/62ac54bac75c24461c5834bec4be4718e5a863f7

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Citations in the corpus

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease (2014, background): “In many ER stressrelated in vitro and in vivo models, ER stress and oxidative stress accentuate each other in a positive feed-forward loop, which interferes with cell function and activates pro-apoptotic signaling (104).”
Oxidative Stress and Antioxidant Defense in Fish: The Implications of Probiotic, Prebiotic, and Synbiotics (2020, background): “All aerobic organisms including fish and shellfish produce ROS through their normal metabolism, especially from mitochondria as well as peroxisomes, endoplasmic reticulum, and plasma membrane (Malhotra and Kaufman 2007, Birnie-Gauvin et al. 2017; Xie et al. 2019).”
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress (2012, background): “Recently, reactive oxygen species (ROS) have emerged as crucial regulators of ER function and UPR activation and in several diseased conditions, ER stress and increased ROS production occur concurrently.(4) Although our appreciation of the close association between oxidative stress and ER stress is ”
From endoplasmic-reticulum stress to the inflammatory response (2008, background): “Through this forward cycle, calcium release, ROS production and protein misfolding function together to activate calcium-dependent protein kinases, as well as JNK and NF-κB, leading to inflammatory responses and even cell deat”
Role of ROS and RNS Sources in Physiological and Pathological Conditions (2016, background): “Abnormalities in insulin metabolism are associated with APOE status.”
Toll-like receptor activation of XBP1 regulates innate immune responses in macrophages (2010, background): “Notably, oxidative stress has been shown to promote ER stres”
Oxidant Mechanisms in Renal Injury and Disease (2016, neutral): “The endoplasmic reticulum generates ROS as a by-product of protein folding and oxidation (173).”