Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

By E. Lubos, Joseph Loscalzo, Diane E. Handy. Antioxidants and Redox Signaling, 2011

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The cytoprotective role of the Keap1–Nrf2 pathway (2011, background): “The transcriptional regulation of glutathione peroxidase 2 (and possibly also glutathione peroxidase 1) is Nrf2 dependent (Lubos et al. 2010).”
Selenoproteins: molecular pathways and physiological roles. (2014, background): “This cytosolic enzyme catalyzes glutathione (GSH)-dependent reduction of hydrogen peroxide to water (235).”
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants (2024, background): “Selenocysteine is also known as the 21st amino acid in the genetic code and plays an important role in the enzymatic reduction of hydrogen peroxide and hydroperoxides (Handy and Loscalzo 2022; Lubos et al. 2011).”
Selenium, Selenoproteins, and Immunity (2018, background): “Glutathione peroxidase 1 GPX1, cytosolic glutathione peroxidase Reduces cellular H2O2 [22,23].”