Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi.

By Erbay Yigit, Pedro J. Batista, Y. Bei, K. Pang, Chun-Chieh G. Chen, Niraj Tolia, L. Joshua-Tor, S. Mitani, M. J. Simard, C. Mello. Cell, 2006

691 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c3632873244179bda742fdf6c7d7f7a168ce4c17

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Citations in the corpus

Origins and Mechanisms of miRNAs and siRNAs (2009, background): “The Argonaute superfamily can be divided into three separate subgroups: the Piwi clade that binds piRNAs, the Ago clade that associates with miRNAs and siRNAs, and a third clade that has only been described thus far in nematodes (Yigit et al., 2006).”
Argonaute proteins: key players in RNA silencing (2008, background): “melanogaster PIWI (P-element induced wimpy testis); and the recently identified Caenorhabditis elegans -specific group 3 Argonaute”
Many roads to maturity: microRNA biogenesis pathways and their regulation (2009, result): “This early function of Ago2 in miRNA processing might explain why it associates with the RLC before the pre-miRNA and corroborates earlier findings in other species that Ago proteins are active players in miRNA biogenesi”
Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. (2008, background): “C. elegans has 27 Argonaute proteins that must distinguish between primary and secondary siRNAs bearing monophosphate and triphosphate termini, respectively (Pak and Fire, 2007; Sijen et al., 2007; Yigit et al., 2006 ).”
PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. (2008, methodology): “Yet, beyond a general requirement for fertility ( Yigit et al., 2006 ), the function of C. elegans Piwi-related AGOs and the nature of their small-RNA cofactors had not been explored.”
Antiviral immunity directed by small RNAs. (2007, positive): “It will be important to determine which proportion of viRNAs have the distinctive features of (c)RNAs because the (c)RNAs involved in experimental RNAi are only in their minority associated with the AGO homolog RDE1 (Yigit et al., 2006), which is, nonetheless, crucial for antiviral defense.”
Small RNA sorting: matchmaking for Argonautes (2010, background): “Argonaute proteins can be classified into three subgroups according to their sequence relationships: the AGO subfamily, the Piwi subfamily and the worm-specific WAGO clad”
RNA-based antiviral immunity (2010, background): “elegans , primary and secondary siRNAs from exogenous dsRNA bind to specific AGO effector protein”
An endogenous small interfering RNA pathway in Drosophila (2008, background): “Among animals, endo-siRNA pathways have so far been restricted to Caenorhabditis elegans 24–27 .”
piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans (2012, background): “Secondary siRNA pathways in C. elegans are complex, can involve many different AGO proteins, and are only partly understood (Yigit et al., 2006).”
Specialization and evolution of endogenous small RNA pathways (2007, neutral): “elegans has expanded to contain 27 predicted members, all of which have been analysed using forward or reverse genetics or biochemical approache”