Many roads to maturity: microRNA biogenesis pathways and their regulation

By Julia Winter, Stephanie Jung, Sarina Keller, Richard I. Gregory, Sven Diederichs. Nature Cell Biology, 2009

2,739 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/27ea8047bcd724e8217bd0c8c32e31a0d5a2c7df

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In Cancer Research

1. John S. Mattick
2. David Baltimore
3. D. Rao
4. Marcel E. Dinger
5. Ryan M. O’Connell
6. Tim R. Mercer
7. Aadel A Chaudhuri
8. Nikolaus Rajewsky

In Molecular Biology

1. John S. Mattick
2. David P. Bartel
3. Marcel E. Dinger
4. David Baltimore
5. Tim R. Mercer
6. Ryan M. O’Connell
7. D. Rao
8. Nikolaus Rajewsky

Citations in the corpus

• Physiological and pathological roles for microRNAs in the immune system (2010, background): “The processes of miRNA biogenesis and target mRNA repression have been intensively studied in recent year”
• Evolution and Functional Diversification of MIRNA Genes (2011, background): “An average animal pri-miRNA contains a 33bp stem with a terminal loop and two single-stranded flanking regions (Winter et al., 2009).”
• Rapid electronic detection of probe-specific microRNAs using thin nanopore sensors. (2010, background): “1 ), are small endogenous biomolecules that have an important regulatory role in embryonic differentiation, haematopoiesis, cardiac hypertrophy and a variety of cancer”
• Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA (2017, background): “Short ncRNAs include the relatively wellknown microRNAs (miRNAs) [9,10], as well as smallinterfering RNAs (siRNAs) and P-element-induced wimpy testis (PIWI)-interacting RNA (piRNAs) [11], which generally act to negatively regulate gene expression.”
• Non‐coding RNAs: regulators of disease (2010, background): “Likewise, the pluripotency factor LIN28 can bind to the conserved loop of the primary let-7 transcript (pri-let-7) to directly inhibit the Drosha cleavage steps [75–77] and can inhibit Dicer cleavage directly or by facilitating premiRNA degradation [78,79].”
• Regulation of mRNA translation and stability by microRNAs. (2010, background): “Other reviews discuss biogenesis (30, 31) and biological functions (2–4, 32) of miRNAs.”
• The widespread regulation of microRNA biogenesis, function and decay (2010, background): “Recent work has identified a battery of proteins that regulate processing (either positively or negatively) either by interacting with Drosha or Dicer or by binding to miRNA precursor”
• MicroRNAs in human cancer. (2013, background): “miRNA biogenesis has been reviewed extensively [ 56, 67– 73 ] (Fig.”
• miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades (2011, background): “The majority of animal miRNAs are transcribed as long primary transcripts from which one or more (cid:2) 70nt long hairpin precursors (pre-miRNAs) are cleaved out by the Drosha endonuclease (1).”
• Transcriptional Regulation by Nrf2 (2017, background): “expression by sequence-specific binding with mRNA molecules and consequent inhibition of translation or degradation of the targets (181).”
• Nanoparticles for Cancer Therapy: Current Progress and Challenges (2021, background): “MicroRNA are a class of endogenous “single-stranded non-coding RNA” molecules that control post transcription gene expression by blocking translation of the target mRNA or repressing protein production by destabilizing mRNA [170].”
• microRNAs and the immune response (2009, background): “These short RNA sequences of 20–23 nucleotides in length are produced by the processing of full length mRNA-like transcripts [1,2].”