Argonaute proteins: key players in RNA silencing

By Gyorgy Hutvagner, M. J. Simard. Nature reviews. Molecular cell biology, 2008

1,371 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/aeb88e54c9a0fe83f448b84e3ebe6d57c79f19cc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Development of RNA profiling tools and the implementation in forensic casework (2014, background): “miRNAs are small (20–24 nucleotides) regulatory RNAs which are strongly associated with members of a class of proteins called Argonautes [14], which makes them very stable and advantageous when dealing with degraded forensic samples [15,16].”
RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex (2009, positive): “…core components of the eukaryotic RNAi machinery has led to a tremendous variety of observed RNA-mediated gene silencing pathways that can act at post-transcriptional or transcriptional levels (Chapman and Carrington, 2007; Zaratiegui et al., 2007; Farazi et al., 2008; Hutvagner and Simard, 2008).”
PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. (2008, background): “In canonical RNAi pathways, double-stranded RNA (dsRNA) is processed by members of the Dicer family of multifunctional ribonucleases into 21‐24 nucleotide (nt) short interfering RNAs (siRNAs) that interact with and guide AGO proteins to complementary target sequences in the cell (reviewed in Hutvag”
A three-dimensional view of the molecular machinery of RNA interference (2009, background): “These small RNAs subsequently associate with members of the Argonaute family of proteins, which function as the core components of a diverse set of protein–RNA complexes called RNA-induced silencing complexes (RISCs”
Role of miRNAs and siRNAs in biotic and abiotic stress responses of plants (2011, positive): “Only one strand of the processed small RNA duplex subsequently associates with an RNA-induced silencing complex (RISC) that scans for nucleic acids complementary to the loaded small RNA to execute its function [25, 26].”
Small RNA sorting: matchmaking for Argonautes (2010, background): “Argonaute proteins can be classified into three subgroups according to their sequence relationships: the AGO subfamily, the Piwi subfamily and the worm-specific WAGO clad”
Small RNAs and Their Roles in Plant Development (2009, background): “Argonaute proteins can be divided into two phylogenetic groups based on their sequence relatedness: the argonaute subfamily and the piwi subfamily (reviewed in Hutvagner & Simard 2008).”