An endogenous small interfering RNA pathway in Drosophila

By Benjamin Czech, C. Malone, R. Zhou, Alexander Stark, Catherine Schlingeheyde, Monica Dus, Norbert Perrimon, Manolis Kellis, J. Wohlschlegel, Ravi Sachidanandam and 2 more. Nature, 2008

738 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/43005a4c8dd2d0838cff56ee3dda2c76d2bc4c69

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Citations in the corpus

ShortStack: comprehensive annotation and quantification of small RNA genes. (2013, methodology): “Forty-five out of the 50 such ovarian endo-siRNA loci described by Czech et al. (2008) overlapped with one or more Short-Stack-annotated small RNA clusters.”
Non‐coding RNAs: regulators of disease (2010, background): “Although exogenous siRNAs were discovered a decade ago, endogenous siRNAs (endosiRNAs) have only recently been identified in fruitflies and mammals [50–58], where their biogenesis is dependent on Dicer processing of duplexes formed by overlapping transcripts or long perfect hairpin structures.”
Long noncoding RNAs: functional surprises from the RNA world. (2009, background): “Like pseudogenes, some natural antisense transcripts (NATs) are able to hybridize to overlapping genes and generate endo-siRNAs (Czech et al. 2008; Ghildiyal et al. 2008; Okamura et al. 2008; Watanabe et al. 2008).”
Regulatory roles of natural antisense transcripts (2009, background): “melanogaster S2 cells do not generate endogenous siRNA”
Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing (2010, background): “To find the miRNAs for which knocking down the biogenesis components had a detectable impact, the top 100 miRNA (or miRNA*) species sequenced from S2 cells (Czech et al., 2008) were screened, requiring that the miRNA canonical 8-mer site be associated with mRNAs derepressed in knockdown cells with s”
Diversity and dynamics of the Drosophila transcriptome (2014, neutral): “Cis-NAT-siRNA production typically involves convergent transcription units that overlap on their 3' ends, but other documented loci generate siRNAs across internal exons, introns or 5'UTRs 37,38,39 .”
Biogenesis of small RNAs in animals (2009, background): “Despite their similarity with miRNAs in terms of their association with Ago-subfamily proteins, endo-siRNAs differ from miRNAs in that they are derived from long double-stranded RNAs (dsRNAs) and are dependent only on Dicer and not on Drosh”