Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins.

By Frédéric Legros, A. Lombès, P. Frachon, M. Rojo. Molecular Biology of the Cell, 2002

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View Paper: https://www.semanticscholar.org/paper/c126bc6b2c909401f3c41190444ad889779d2846

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Citations in the corpus

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency (2013, background): “Mitofusins (MFN) 1 and 2, highly homologous dynamin-related proteins of the OMM, orchestrate fusion (Santel and Fuller, 2001; Legros et al., 2002; Chen et al., 2003; Santel et al., 2003).”
Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. (2008, background): “This property is supported by numerous studies showing that depletion of ATP either by inhibiting ATP synthase [52,53], collapsingΔψm [45,54–56] or inhibiting Na/K ATPase [53] trigger general fragmentation of the mitochondrial web.”
Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity (2004, background): “The mitochondrial fusion reaction in cultured cells is strongly inhibited by a protonophore, carbonyl cyanid mchlorophenylhydrazone (CCCP), indicating that the reaction depends on the ∆Ψ across the inner membrane (Legros et al., 2002; Ishihara et al., 2003).”
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy (2008, background): “While previous studies have demonstrated that uncoupling drugs cause overall mitochondrial fragmentation and arrest fusion (Legros et al, 2002; Ishihara et al, 2003; Meeusen et al, 2004; Malka et al, 2005), the relevance of these observations The EMBO Journal VOL 27 | NO 2 | 2008 &2008 European…”
Mitochondrial dynamics in mammalian health and disease. (2009, methodology): “In contrast, the overexpression of DRP1 does not always split the mitochondrial network, which is probably dependent on its overexpression levels and on recruitment to mitochondria (148, 182, 289).”
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy (2008, background): “Depolarization of mitochondria is known to induce their fragmentation into multiple smaller organelles ( Legros et al., 2002 ) by inhibiting organelle fusion ( Meeusen et al., 2004 ).”
Mitochondrial fusion and fission in mammals. (2006, background): “If two parental cells containing fluorescently labeled mitochondria are fused, mitochondrial fusion can be quantified in the cell hybrids by scoring for colocalization of fluorophores (Chen et al. 2003, Ishihara et al. 2003, Legros et al. 2002, Mattenberger et al. 2003).”
Calcium, ATP, and ROS: a mitochondrial love-hate triangle. (2004, background): “Fusion is also mediated by GTPases; mitofusin (Mfn) is an outer membrane anchored GTPase and a homolog of the Drosophila “fuzzy onion” protein (31, 67, 85, 104, 158, 163, 164).”
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure (2013, background): “Indeed, oligomycin, which markedly increases membrane potential (up to 220 mV in isolated mitochondria; see the ‘‘Regulation of Cellular Bioenergetics by Nutrients’’ section) was shown to cause fragmentation (Legros et al., 2002).”