Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

By L. Galluzzi, Ilio Vitale, S. Aaronson, J. Abrams, D. Adam, P. Agostinis, E. Alnemri, L. Altucci, I. Amelio, David W. Andrews and 159 more. Cell Death and Differentiation, 2018

5,732 citations recorded by the source corpus.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/27bba2d44f3e4e552db332b348a2d09a5e96f974

How researchers see this paper

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In Epidemiology

1. Guido Kroemer
2. L. Galluzzi
3. Douglas R. Green
4. D. Tang
5. R. Kang
6. Beth Levine
7. Xin Chen
8. D. Klionsky

In Molecular Biology

1. Guido Kroemer
2. D. Tang
3. L. Galluzzi
4. R. Kang
5. Xin Chen
6. Douglas R. Green
7. D. Klionsky
8. Jiao Liu

Citations in the corpus

• Autophagy-Dependent Ferroptosis: Machinery and Regulation (2020, background): “Notably, the conditional depletion of GPX4 in tissues or cells can cause oxidative injury or cell death in both ferroptosis-dependent and -independent manners (Canli et al., 2016; Cole-Ezea et al., 2012; Friedmann Angeli et al., 2014; Kang et al., 2018a; Matsushita et al., 2015; Ran et al., 2006; Ra”
• Lysosomes as a therapeutic target (2019, methodology): “been adopted by the community, leading to much eas ier understanding between researchers worldwide 233 .”
• The Tumor Suppressor Protein p53 and the Ferroptosis Network (2018, positive): “Since its discovery in 2012 [15], the study of ferroptosis has been a fast-growing field in cell death research [16].”
• Inflammation and Cancer: Triggers, Mechanisms and Consequences (2019, background): “Moreover, many tumors are deficient in apoptotic cell death and therefore cell death by necrosis may be more immunostimulatory (Galluzzi et al., 2018; Weinlich et al., 2017).”
• Pattern Recognition Receptors and the Host Cell Death Molecular Machinery (2018, methodology): “For information regarding other cell death modes please refer to the work published by the Nomenclature on Cell Death Committee 2018 (8)”